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• W2120722011 abstract "The Salmonella species Typhimurium and Enteritidis form the mostimportant causes of food poisoning. Immunity to Salmonellae requiresinnate and specific immune responses. Reported here are the geneticpolymorphisms in the genes of Nramp1, Toll-like receptors and CD14related to the innate immune response to Salmonellae. Salmonella speciesare typically associated with the intra-cellular pathogens capable ofsurviving and replicating intra-cellularly in the phagocyte. Consequently, an adequate T-lymphocyte type 1 response is required toeliminate the parasite. The genetic factors that determine thesusceptibility of the host to Salmonella infection are described below. Mutations in the human genes of some crucial cytokines of the type 1pathway, like IFN-, IL-12 and IL-18, greatly reduce the naturalresistance to Salmonella infections. Mutations in the human genes ofthis type 1 pathway are, by definition, seldom found in humans. Byinvestigating the more frequently occurring (more than 1% of thepopulation) polymorphisms in type 1 cytokines, and those of the innateimmune response, one can assess the relative risk of geneticsusceptibility at population level. In conclusion, it is feasible anduseful to perform population studies on the effect of geneticpolymorphisms on the susceptibility of the host. Such studies, notdescribed to date, are important in the risk assessment of Salmonellaefood poisoning. Suggestions and recommendations are presented here forstudying the genetic factors in the host resistance to salmonellainfections in human and animal models." @default.
• W2120722011 created "2016-06-24" @default.
• W2120722011 creator A5000300655 @default.
• W2120722011 creator A5048498625 @default.
• W2120722011 creator A5073221687 @default.
• W2120722011 creator A5078384598 @default.
• W2120722011 date "2005-07-14" @default.
• W2120722011 modified "2023-09-24" @default.
• W2120722011 title "Genetic susceptibility for Salmonella infections" @default.
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