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- W2120763949 abstract "<20ng/mL, GS 8 pts,) underwent the procedure. Mean age was 71 years. CT-simulation was performed 5 days after the implant (empty rectum, full bladder). MRI (T2 without contrast agent) was also obtained for optimal gel visualization. Treatment-planning was carried out on fused image sets. Prescription dose was 70 Gy in 28 fractions of 2.5 Gy. A single 358 arc rotation was used in all cases. IGRT verification (KV-ConeBeam-CT) was daily for the first three sessions and, subsequently, every 5 sessions. Weekly toxicity evaluations were performed. Results: Overall, the procedure was well tolerated. One patient developed a complication (G2) two weeks following the procedure, with the onset of acute rectal pain and bleeding due to a rectal ulcer confirmed by endoscopy. Resolution of the symptoms occurred in about one month and healing of the ulcer was confirmed endoscopically after two months. At CT-simulation complete disappearance of the gel was observed. Dosimetric analysis for the remainder 11 cases showed a mean separation of 1.22 cm (range, 0.97-1.7 cm) between the anterior rectal wall and the prostate, resulting in significantly improved rectum DVHs, particularly at high dose. All 11 evaluable patients started radiation therapy within 2 weeks following implantation. Acute toxicity was as follows: one case of acute G1 proctitis; 2 cases of G1 and 3 cases of G2 cystitis. Conclusions: PEG gel spacer implants are relatively easy to perform and entail a short learning curve. Patients’ compliance and tolerance are very good. Due to reduced exposure of the rectum to the high dose region, lower acute and late rectal toxicities are to be expected. Further assessment of the benefit of this approach using more extreme hypofractionation schedules is currently ongoing. Author Disclosure: C. Greco: None. M. Panichi: None. M. Coppola: None. G. Morelli: None. F. Pasqualetti: None. A. Sainato: None. G. Pomara: None. L. Tana: None." @default.
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- W2120763949 date "2012-11-01" @default.
- W2120763949 modified "2023-09-27" @default.
- W2120763949 title "Do Prostate Cancer Patients With Extremely High PSA Benefit From Radiation Therapy? A Population Based Study" @default.
- W2120763949 doi "https://doi.org/10.1016/j.ijrobp.2012.07.1039" @default.
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