Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120764395> ?p ?o ?g. }
- W2120764395 endingPage "64" @default.
- W2120764395 startingPage "43" @default.
- W2120764395 abstract "Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus–associated disease (PCVAD). The virus preferentially targets the lymphoid tissues, which leads to lymphoid depletion and immunosuppression in pigs. The disease is exacerbated by immunostimulation or concurrent infections with other pathogens. PCV2 resides in certain immune cells, such as macrophage and dendritic cells, and modulates their functions. Upregulation of IL-10 and proinflammatory cytokines in infected pigs may contribute to pathogenesis. Pig genetics influence host susceptibility to PCV2, but the viral genetic determinants for virulence remain unknown. PCV2 DNA and proteins interact with various cellular genes that control immune responses to regulate virus replication and pathogenesis. Both neutralizing antibodies and cell-mediated immunity are important immunological correlates of protection. Despite the availability of effective vaccines, variant strains of PCV2 continue to emerge. Although tremendous progress has been made toward understanding PCV2 pathogenesis and immune interactions, many important questions remain." @default.
- W2120764395 created "2016-06-24" @default.
- W2120764395 creator A5075780100 @default.
- W2120764395 date "2013-01-01" @default.
- W2120764395 modified "2023-10-17" @default.
- W2120764395 title "Porcine Circovirus Type 2 (PCV2): Pathogenesis and Interaction with the Immune System" @default.
- W2120764395 cites W1502223717 @default.
- W2120764395 cites W1580682124 @default.
- W2120764395 cites W1813135772 @default.
- W2120764395 cites W1968987300 @default.
- W2120764395 cites W1970948214 @default.
- W2120764395 cites W1971349089 @default.
- W2120764395 cites W1974018869 @default.
- W2120764395 cites W1974293368 @default.
- W2120764395 cites W1975140257 @default.
- W2120764395 cites W1975972985 @default.
- W2120764395 cites W1976992846 @default.
- W2120764395 cites W1977563342 @default.
- W2120764395 cites W1978287281 @default.
- W2120764395 cites W1979195376 @default.
- W2120764395 cites W1979790197 @default.
- W2120764395 cites W1980039136 @default.
- W2120764395 cites W1980539704 @default.
- W2120764395 cites W1981874008 @default.
- W2120764395 cites W1982770879 @default.
- W2120764395 cites W1983170246 @default.
- W2120764395 cites W1983422799 @default.
- W2120764395 cites W1983844170 @default.
- W2120764395 cites W1989496706 @default.
- W2120764395 cites W1990208489 @default.
- W2120764395 cites W1990371867 @default.
- W2120764395 cites W1990532952 @default.
- W2120764395 cites W1990559162 @default.
- W2120764395 cites W1994940642 @default.
- W2120764395 cites W1996313933 @default.
- W2120764395 cites W2003624287 @default.
- W2120764395 cites W2009484599 @default.
- W2120764395 cites W2009834954 @default.
- W2120764395 cites W2010239332 @default.
- W2120764395 cites W2011043840 @default.
- W2120764395 cites W2012713635 @default.
- W2120764395 cites W2012923573 @default.
- W2120764395 cites W2017412786 @default.
- W2120764395 cites W2017957562 @default.
- W2120764395 cites W2018153336 @default.
- W2120764395 cites W2019208496 @default.
- W2120764395 cites W2020363525 @default.
- W2120764395 cites W2020954544 @default.
- W2120764395 cites W2021082618 @default.
- W2120764395 cites W2023063523 @default.
- W2120764395 cites W2027179240 @default.
- W2120764395 cites W2035108540 @default.
- W2120764395 cites W2035406498 @default.
- W2120764395 cites W2036442819 @default.
- W2120764395 cites W2037239097 @default.
- W2120764395 cites W2039754073 @default.
- W2120764395 cites W2040722908 @default.
- W2120764395 cites W2041059341 @default.
- W2120764395 cites W2041146694 @default.
- W2120764395 cites W2042106632 @default.
- W2120764395 cites W2043203206 @default.
- W2120764395 cites W2043580689 @default.
- W2120764395 cites W2045301088 @default.
- W2120764395 cites W2047255379 @default.
- W2120764395 cites W2049269231 @default.
- W2120764395 cites W2050968243 @default.
- W2120764395 cites W2055556815 @default.
- W2120764395 cites W2056075845 @default.
- W2120764395 cites W2056883351 @default.
- W2120764395 cites W2058678368 @default.
- W2120764395 cites W2059291638 @default.
- W2120764395 cites W2059866651 @default.
- W2120764395 cites W2060605949 @default.
- W2120764395 cites W2063135547 @default.
- W2120764395 cites W2064877211 @default.
- W2120764395 cites W2067621873 @default.
- W2120764395 cites W2068040541 @default.
- W2120764395 cites W2069020968 @default.
- W2120764395 cites W2077309978 @default.
- W2120764395 cites W2079140447 @default.
- W2120764395 cites W2082265400 @default.
- W2120764395 cites W2082768897 @default.
- W2120764395 cites W2085976583 @default.
- W2120764395 cites W2087537336 @default.
- W2120764395 cites W2088467377 @default.
- W2120764395 cites W2089127440 @default.
- W2120764395 cites W2091564154 @default.
- W2120764395 cites W2093720299 @default.
- W2120764395 cites W2096838352 @default.
- W2120764395 cites W2097112899 @default.
- W2120764395 cites W2098995386 @default.
- W2120764395 cites W2100072399 @default.
- W2120764395 cites W2105173742 @default.
- W2120764395 cites W2106638291 @default.
- W2120764395 cites W2107865312 @default.
- W2120764395 cites W2109857754 @default.
- W2120764395 cites W2109938430 @default.
- W2120764395 cites W2111970919 @default.