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• W2120768548 abstract "The concept of the excitatory action of GABA during early development is based on data obtained mainly in brain slice recordings. However, in vivo measurements as well as observations made in intact hippocampal preparations indicate that GABA is in fact inhibitory in rodents at early neonatal stages. The apparent excitatory action of GABA seems to stem from cellular injury due to the slicing procedure, which leads to accumulation of intracellular Cl(-) in injured neurons. This procedural artifact was shown to be attenuated through various manipulations such as addition of energy substrates more relevant to the in vivo situation. These observations question the very concept of excitatory GABA in immature neuronal networks." @default.
• W2120768548 created "2016-06-24" @default.
• W2120768548 creator A5038141417 @default.
• W2120768548 creator A5071240109 @default.
• W2120768548 date "2012-01-01" @default.
• W2120768548 modified "2023-10-14" @default.
• W2120768548 title "Excitatory GABA: How a Correct Observation May Turn Out to be an Experimental Artifact" @default.
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• W2120768548 doi "https://doi.org/10.3389/fphar.2012.00065" @default.

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