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- W2120784146 abstract "The main function of platelets, the maintenance of hemostasis, depends on three of their properties, the endothelial supporting function of platelets, the ability to form hemostatic plugs and to release lipoprotein material (platelet factor 3). When the number of circulating platelets is reduced the capillary endothelium becomes weakened as platelets are not available to enter the endothelial cytoplasm to support it and the capillary wall ruptures when exposed to minor trauma. The bleeding through the ruptured vessel wall is arrested by formation of a clump of platelets forming a hemostatic plug. Damage to the vessel wall initiates both the coagulation mechanisms and degradation of adenosine triphosphate. The products of each of these reactions, namely, thrombin and adenosine diphosphate bring about aggregation of platelets to form the hemostatic plug. These are the platelet functions performed following a transfusion of platelets into a thrombocytopenic recipient. The platelets remaining in the circulation and which are counted in platelet survival studies are those in excess of the immediate need of the recipient." @default.
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- W2120784146 date "1966-01-02" @default.
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- W2120784146 title "The Function of Platelets" @default.
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- W2120784146 doi "https://doi.org/10.1111/j.1537-2995.1966.tb04686.x" @default.
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