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- W2120798255 abstract "The set of conserved eukaryotic protein-coding genes includes distinct subsets one of which appears to be most closely related to and, by inference, derived from archaea, whereas another one appears to be of bacterial, possibly, endosymbiotic origin. The archaeal genes of eukaryotes, primarily, encode components of information-processing systems, whereas the bacterial genes are predominantly operational. The precise nature of the archaeo-eukaryotic relationship remains uncertain, and it has been variously argued that eukaryotic informational genes evolved from the homologous genes of Euryarchaeota or Crenarchaeota (the major branches of extant archaea) or that the origin of eukaryotes lies outside the known diversity of archaea. We describe a comprehensive set of 355 eukaryotic genes of apparent archaeal origin identified through ortholog detection and phylogenetic analysis. Phylogenetic hypothesis testing using constrained trees, combined with a systematic search for shared derived characters in the form of homologous inserts in conserved proteins, indicate that, for the majority of these genes, the preferred tree topology is one with the eukaryotic branch placed outside the extant diversity of archaea although small subsets of genes show crenarchaeal and euryarchaeal affinities. Thus, the archaeal genes in eukaryotes appear to descend from a distinct, ancient, and otherwise uncharacterized archaeal lineage that acquired some euryarchaeal and crenarchaeal genes via early horizontal gene transfer." @default.
- W2120798255 created "2016-06-24" @default.
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- W2120798255 date "2008-04-23" @default.
- W2120798255 modified "2023-09-26" @default.
- W2120798255 title "The Deep Archaeal Roots of Eukaryotes" @default.
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- W2120798255 doi "https://doi.org/10.1093/molbev/msn108" @default.
- W2120798255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2464739" @default.
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- W2120798255 hasPublicationYear "2008" @default.
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