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- W2120809043 abstract "The use of kidneys from deceased donors considered at increased infectious risk represents a strategy to increase the donor pool.Single-institution longitudinal observational study.Tertiary care center.Fifty patients who gave special informed consent to receive Centers for Disease Control and Prevention high-risk (CDCHR) donor kidneys were followed up by serial testing for viral transmission after transplantation. Nucleic acid testing for human immunodeficiency virus, hepatitis B virus, and hepatitis C virus was performed on all high-risk donors before transplantation. Outcomes of CDCHR kidney recipients were compared with outcomes of non-high-risk (non-HR) kidney recipients.New viral transmission, graft function, and waiting list time.No recipient seroconversion was detected during a median follow-up period of 11.3 months. Compared with non-HR donors, CDCHR donors were younger (mean [SD] age, 35 [11] vs 43 [18] years, P = .01), fewer were expanded criteria donors (2.0% vs 24.8%, P < .001), and fewer had a terminal creatinine level exceeding 2.5 mg/dL (4.0% vs 8.8%, P = .002). The median creatinine levels at 1 year after transplantation were 1.4 (interquartile range, 1.2-1.7) mg/dL for CDCHR recipients and 1.4 (interquartile range, 1.1-1.9) mg/dL for non-HR recipients (P = .4). Willingness to accept a CDCHR kidney significantly shortened the median waiting list time (274 vs 736 days, P < .001).We show safe use of CDCHR donor kidneys and good 1-year graft function. With continued use of these organs and careful follow-up care, we will be better able to gauge donor risk and match it to recipient need to expand the donor pool and optimize patient benefit." @default.
- W2120809043 created "2016-06-24" @default.
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- W2120809043 date "2011-11-01" @default.
- W2120809043 modified "2023-09-30" @default.
- W2120809043 title "Outcomes of Renal Transplants From Centers for Disease Control and Prevention High-Risk Donors With Prospective Recipient Viral Testing" @default.
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- W2120809043 doi "https://doi.org/10.1001/archsurg.2011.267" @default.
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