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- W2120809344 abstract "Nano-scaled cantilever-like springs are being developed using electron-beam lithography for an ultra sensitive bio- assay. The flexible nature of the technology has the potential to offer high-throughput detection of proteins, DNA, and RNA for a broad range of applications ranging from disease diagnosis to biological weapons detection. The nano- cantilevers can be individually coated with specific reagents to detect and measure the presence of particular antigens and/or complementary DNA sequences with a smaller sample size and at much earlier stages of disease progression compared to current medical diagnostic technologies. The fabrication of nano-cantilevers uses sputter deposition, lift- off, and electron-beam lithography. Using the cantilever material stack (Au/Cr/Si), we then assessed the binding affinity of Au, Cr, and Si with Protein G, and antibodies for Prostate Specific Antigen (PSA) and Cancer Antigen 125 (CA125), an ovarian cancer-associated antigen. The thin gold layer of the Au/Cr/Si samples, provided increased binding affinity for each of the biomaterials tested. The chromium layer has a similar, if not less, binding affinity compared to the silicon chip alone." @default.
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- W2120809344 date "2005-07-28" @default.
- W2120809344 modified "2023-09-23" @default.
- W2120809344 title "Array of Nano-Cantilevers as a Bio-Assay for Cancer Diagnosis" @default.
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- W2120809344 doi "https://doi.org/10.1109/ectc.2005.1441327" @default.
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