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- W2120822015 abstract "Up-regulation of the type 2 cannabinoid receptor (CB2R) has been reported in (neuro)inflammatory diseases. In this study, we report the preclinical evaluation of [11C]NE40 as positron emission tomography (PET) radioligand for visualization of the CB2R. The selectivity of NE40 for CB2R and its toxicity and mutagenicity were determined. [11C]NE40 was evaluated by biodistribution and autoradiography studies in normal rats and a microPET study in normal mice, rats and a rhesus monkey. Specific in vivo binding of [11C]NE40 to human CB2R (hCB2R) was studied in a rat model with hCB2R overexpression. [11C]NE40 shows specific CB2R binding in the spleen and blood of normal rats and high brain uptake in rhesus monkey. [11C]NE40 showed specific and reversible binding to hCB2R in vivo in a rat model with local hCB2R overexpression. [11C]NE40 shows favorable characteristics as radioligand for in vivo visualization of the CB2R and is a promising candidate for hCB2R PET imaging." @default.
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- W2120822015 date "2012-04-01" @default.
- W2120822015 modified "2023-10-10" @default.
- W2120822015 title "Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer" @default.
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- W2120822015 doi "https://doi.org/10.1016/j.nucmedbio.2011.09.005" @default.
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