FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120836974> ?p ?o ?g. }

• W2120836974 abstract "Basement membranes in the walls of cerebral capillaries and arteries form a major lymphatic drainage pathway for fluid and solutes from the brain. Amyloid-β (Aβ) draining from the brain is deposited in such perivascular pathways as cerebral amyloid angiopathy (CAA) in Alzheimer's disease (AD). CAA increases in severity when Aβ is removed from the brain parenchyma by immunotherapy for AD. In this study we investigated the consequences of immune complexes in artery walls upon drainage of solutes similar to soluble Aβ. We tested the hypothesis that, following active immunization with ovalbumin, immune complexes form within the walls of cerebral arteries and impair the perivascular drainage of solutes from the brain. Mice were immunized against ovalbumin and then challenged by intracerebral microinjection of ovalbumin. Perivascular drainage of solutes was quantified following intracerebral microinjection of soluble fluorescent 3kDa dextran into the brain at different time intervals after intracerebral challenge with ovalbumin.Ovalbumin, IgG and complement C3 co-localized in basement membranes of artery walls 24 hrs after challenge with antigen; this was associated with significantly reduced drainage of dextran in immunized mice.Perivascular drainage along artery walls returned to normal by 7 days. These results indicate that immune complexes form in association with basement membranes of cerebral arteries and interfere transiently with perivascular drainage of solutes from the brain. Immune complexes formed during immunotherapy for AD may similarly impair perivascular drainage of soluble Aβ and increase severity of CAA." @default.
• W2120836974 created "2016-06-24" @default.
• W2120836974 creator A5006322965 @default.
• W2120836974 creator A5018678010 @default.
• W2120836974 creator A5024080164 @default.
• W2120836974 creator A5044019815 @default.
• W2120836974 creator A5049207875 @default.
• W2120836974 creator A5053163430 @default.
• W2120836974 creator A5091381850 @default.
• W2120836974 date "2013-08-09" @default.
• W2120836974 modified "2023-10-14" @default.
• W2120836974 title "Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease" @default.
• W2120836974 cites W1496503766 @default.
• W2120836974 cites W1616122655 @default.
• W2120836974 cites W1671478575 @default.
• W2120836974 cites W1693283493 @default.
• W2120836974 cites W1970650461 @default.
• W2120836974 cites W1970773611 @default.
• W2120836974 cites W1974894459 @default.
• W2120836974 cites W1979221664 @default.
• W2120836974 cites W1979415323 @default.
• W2120836974 cites W1996736279 @default.
• W2120836974 cites W2013274571 @default.
• W2120836974 cites W2024262813 @default.
• W2120836974 cites W2042282383 @default.
• W2120836974 cites W2063236931 @default.
• W2120836974 cites W2063909850 @default.
• W2120836974 cites W2069168024 @default.
• W2120836974 cites W2083806757 @default.
• W2120836974 cites W2084559483 @default.
• W2120836974 cites W2084962353 @default.
• W2120836974 cites W2089430367 @default.
• W2120836974 cites W2116163670 @default.
• W2120836974 cites W2122843800 @default.
• W2120836974 cites W2128307173 @default.
• W2120836974 cites W2129285485 @default.
• W2120836974 cites W2135780456 @default.
• W2120836974 cites W2144893051 @default.
• W2120836974 cites W2148034536 @default.
• W2120836974 cites W2165503155 @default.
• W2120836974 cites W2171083417 @default.
• W2120836974 cites W4234058223 @default.
• W2120836974 doi "https://doi.org/10.1186/2051-5960-1-48" @default.
• W2120836974 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3893559" @default.
• W2120836974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24252464" @default.
• W2120836974 hasPublicationYear "2013" @default.
• W2120836974 type Work @default.
• W2120836974 sameAs 2120836974 @default.
• W2120836974 citedByCount "39" @default.
• W2120836974 countsByYear W21208369742014 @default.
• W2120836974 countsByYear W21208369742015 @default.
• W2120836974 countsByYear W21208369742016 @default.
• W2120836974 countsByYear W21208369742017 @default.
• W2120836974 countsByYear W21208369742018 @default.
• W2120836974 countsByYear W21208369742019 @default.
• W2120836974 countsByYear W21208369742020 @default.
• W2120836974 countsByYear W21208369742021 @default.
• W2120836974 countsByYear W21208369742022 @default.
• W2120836974 countsByYear W21208369742023 @default.
• W2120836974 crossrefType "journal-article" @default.
• W2120836974 hasAuthorship W2120836974A5006322965 @default.
• W2120836974 hasAuthorship W2120836974A5018678010 @default.
• W2120836974 hasAuthorship W2120836974A5024080164 @default.
• W2120836974 hasAuthorship W2120836974A5044019815 @default.
• W2120836974 hasAuthorship W2120836974A5049207875 @default.
• W2120836974 hasAuthorship W2120836974A5053163430 @default.
• W2120836974 hasAuthorship W2120836974A5091381850 @default.
• W2120836974 hasBestOaLocation W21208369741 @default.
• W2120836974 hasConcept C142724271 @default.
• W2120836974 hasConcept C203014093 @default.
• W2120836974 hasConcept C2776946954 @default.
• W2120836974 hasConcept C2777701055 @default.
• W2120836974 hasConcept C2777790613 @default.
• W2120836974 hasConcept C2777799939 @default.
• W2120836974 hasConcept C2779134260 @default.
• W2120836974 hasConcept C2779483572 @default.
• W2120836974 hasConcept C71924100 @default.
• W2120836974 hasConcept C8891405 @default.
• W2120836974 hasConceptScore W2120836974C142724271 @default.
• W2120836974 hasConceptScore W2120836974C203014093 @default.
• W2120836974 hasConceptScore W2120836974C2776946954 @default.
• W2120836974 hasConceptScore W2120836974C2777701055 @default.
• W2120836974 hasConceptScore W2120836974C2777790613 @default.
• W2120836974 hasConceptScore W2120836974C2777799939 @default.
• W2120836974 hasConceptScore W2120836974C2779134260 @default.
• W2120836974 hasConceptScore W2120836974C2779483572 @default.
• W2120836974 hasConceptScore W2120836974C71924100 @default.
• W2120836974 hasConceptScore W2120836974C8891405 @default.
• W2120836974 hasIssue "1" @default.
• W2120836974 hasLocation W21208369741 @default.
• W2120836974 hasLocation W21208369742 @default.
• W2120836974 hasLocation W21208369743 @default.
• W2120836974 hasLocation W21208369744 @default.
• W2120836974 hasLocation W21208369745 @default.
• W2120836974 hasLocation W21208369746 @default.
• W2120836974 hasOpenAccess W2120836974 @default.
• W2120836974 hasPrimaryLocation W21208369741 @default.
• W2120836974 hasRelatedWork W1964674919 @default.
• W2120836974 hasRelatedWork W1970126913 @default.
• W2120836974 hasRelatedWork W1998525778 @default.

• next