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- W2120851086 abstract "Sir, Granulocytic sarcomas are extramedullary tumours composed of malignant myeloid precursor cells.1 They are usually rapidly growing nodular masses with a solid consistency, frequently presenting as a solitary lesion. The tumours most commonly develop in the bone, periosteum, soft tissue, lymph nodes and skin, but they have been found in many other organs, including abdominal organs, testis and breast. Granulocytic sarcomas occur in four clinical situations: (i) in patients with known acute myelogenous leukaemia (AML), (ii) in patients with chronic myelogenous leukaemia or other myeloproliferative disorders of blastic transformation, (iii) in patients with myelodysplastic syndromes, and (iv) in patients without known haematological disorders (isolated granulocytic sarcomas).1, 2 Granulocytic sarcomas remain poorly recognized and are frequently confused with malignant lymphomas especially when they present without any history of antecedent myeloproliferative disorder. CD56, a neural cell adhesion molecule, is expressed on natural killer (NK) cells, on a subset of peripheral CD8+ T cells, on a subset of peripheral monocytes and on neural/neuroendocrine tissues. In haematopoietic neoplasms, CD56 has also been detected on NK cell lymphomas, on a subset of T‐cell lymphomas, on plasma cell myelomas, and on AML.3, 4 We report a case of a CD56+ granulocytic sarcoma." @default.
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- W2120851086 date "2002-09-01" @default.
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- W2120851086 title "Myeloid markers should be undertaken in cases of CD56 positivity to exclude granulocytic sarcoma" @default.
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- W2120851086 doi "https://doi.org/10.1046/j.1365-2133.2002.48654.x" @default.
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