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• W2120867803 abstract "Feed-forward inhibition from molecular layer interneurons onto granule cells (GCs) in the dentate gyrus is thought to have major effects regulating entorhinal–hippocampal interactions, but the precise identity, properties, and functional connectivity of the GABAergic cells in the molecular layer are not well understood. We used single and paired intracellular patch clamp recordings from post-hoc-identified cells in acute rat hippocampal slices and identified a subpopulation of molecular layer interneurons that expressed immunocytochemical markers present in members of the neurogliaform cell (NGFC) class. Single NGFCs displayed small dendritic trees, and their characteristically dense axonal arborizations covered significant portions of the outer and middle one-thirds of the molecular layer, with frequent axonal projections across the fissure into the CA1 and subicular regions. Typical NGFCs exhibited a late firing pattern with a ramp in membrane potential prior to firing action potentials, and single spikes in NGFCs evoked biphasic, prolonged GABAA and GABAB postsynaptic responses in GCs. In addition to providing dendritic GABAergic inputs to GCs, NGFCs also formed chemical synapses and gap junctions with various molecular layer interneurons, including other NGFCs. NGFCs received low-frequency spontaneous synaptic events, and stimulation of perforant path fibers revealed direct, facilitating synaptic inputs from the entorhinal cortex. Taken together, these results indicate that NGFCs form an integral part of the local molecular layer microcircuitry generating feed-forward inhibition and provide a direct GABAergic pathway linking the dentate gyrus to the CA1 and subicular regions through the hippocampal fissure. J. Comp. Neurol. 519:1476–1491, 2011. © 2010 Wiley-Liss, Inc." @default.
• W2120867803 created "2016-06-24" @default.
• W2120867803 creator A5004335920 @default.
• W2120867803 creator A5006038863 @default.
• W2120867803 creator A5025878726 @default.
• W2120867803 creator A5054420671 @default.
• W2120867803 date "2011-04-18" @default.
• W2120867803 modified "2023-10-12" @default.
• W2120867803 title "Neurogliaform cells in the molecular layer of the dentate gyrus as feed-forward γ-aminobutyric acidergic modulators of entorhinal-hippocampal interplay" @default.
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• W2120867803 doi "https://doi.org/10.1002/cne.22577" @default.
• W2120867803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4015525" @default.
• W2120867803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21452204" @default.
• W2120867803 hasPublicationYear "2011" @default.

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