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- W2120872600 abstract "No AccessJournal of UrologyAdult Urology1 Jun 2012The Impact of Real-Time Elastography Guiding a Systematic Prostate Biopsy to Improve Cancer Detection Rate: A Prospective Study of 353 Patients Marko Brock, Christian von Bodman, Rein Jüri Palisaar, Björn Löppenberg, Florian Sommerer, Thomas Deix, Joachim Noldus, and Thilo Eggert Marko BrockMarko Brock Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author , Christian von BodmanChristian von Bodman Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author , Rein Jüri PalisaarRein Jüri Palisaar Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author , Björn LöppenbergBjörn Löppenberg Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author , Florian SommererFlorian Sommerer Department of Pathology, Berufsgenossenschaftliche Universitätsklinik Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany More articles by this author , Thomas DeixThomas Deix Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author , Joachim NoldusJoachim Noldus Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author , and Thilo EggertThilo Eggert Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.01.063AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated whether real-time elastography guided biopsy improves prostate cancer detection compared to conventional systematic gray scale ultrasound guidance. Materials and Methods: A total of 353 consecutive patients suspicious for prostate cancer were prospectively randomized for real-time elastography (178) or gray scale ultrasound (175). Each patient enrolled in the study underwent a 10-core prostate biopsy. Six lateral prostate sectors (base, mid, apex) were scanned for cancer suspicious areas, defined as stiffer blue lesions using real-time elastography and hypoechoic lesions using gray scale ultrasound. Suspicious areas were sampled by a single targeted biopsy and considered representative of a defined prostate sector. If real-time elastography or gray scale ultrasound did not visualize a suspicious area in a sector, the biopsy core was taken systematically. Imaging findings were correlated with histopathological reports. Real-time elastography and gray scale ultrasound cases were compared in terms of cancer detection rate and imaging guidance accuracy. Results: Characteristics of patients undergoing real-time elastography and gray scale ultrasound, including age, prostate specific antigen, prostate volume and digital rectal examination, were not significantly different (p >0.05). Prostate cancer was detected in 160 of 353 patients (45.3%). The prostate cancer detection rate was significantly higher in patients who underwent biopsy with the real-time elastography guided approach compared to the gray scale ultrasound guided biopsy at 51.1% (91 of 178) vs 39.4% (69 of 175) (p = 0.027). Overall sensitivity and specificity to detect prostate cancer was 60.8% and 68.4% for real-time elastography vs 15% and 92.3% for gray scale ultrasound, respectively. Conclusions: Sensitivity to visualize and detect prostate cancer improved using real-time elastography in addition to gray scale ultrasound during prostate biopsy. Overall sensitivity did not reach levels to omit a systematic biopsy approach. 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Google Scholar © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byGhai S, Eure G, Fradet V, Hyndman M, McGrath T, Wodlinger B and Pavlovich C (2016) Assessing Cancer Risk on Novel 29 MHz Micro-Ultrasound Images of the Prostate: Creation of the Micro-Ultrasound Protocol for Prostate Risk IdentificationJournal of Urology, VOL. 196, NO. 2, (562-569), Online publication date: 1-Aug-2016.Schiffmann J, Grindei M, Tian Z, Yassin D, Steinwender T, Leyh-Bannurah S, Randazzo M, Kwiatkowski M, Karakiewicz P, Hammerer P and Manka L (2016) Limitations of Elastography Based Prostate BiopsyJournal of Urology, VOL. 195, NO. 6, (1731-1736), Online publication date: 1-Jun-2016.Boehm K, Salomon G, Beyer B, Schiffmann J, Simonis K, Graefen M and Budaeus L (2014) Shear Wave Elastography for Localization of Prostate Cancer Lesions and Assessment of Elasticity Thresholds: Implications for Targeted Biopsies and Active Surveillance ProtocolsJournal of Urology, VOL. 193, NO. 3, (794-800), Online publication date: 1-Mar-2015. Volume 187Issue 6June 2012Page: 2039-2043 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Keywordselasticity imaging techniquesbiopsyprostatic neoplasmsprostatectomyMetricsAuthor Information Marko Brock Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author Christian von Bodman Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author Rein Jüri Palisaar Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author Björn Löppenberg Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author Florian Sommerer Department of Pathology, Berufsgenossenschaftliche Universitätsklinik Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany More articles by this author Thomas Deix Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author Joachim Noldus Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author Thilo Eggert Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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