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• W2120872734 endingPage "034011" @default.
• W2120872734 startingPage "034011" @default.
• W2120872734 abstract "Infrared (IR) spectroscopy is one of the most chemically specific analytical methods that gives information about composition, structure, and interactions in a material. IR spectroscopy has been successfully applied to study the permeation of xenobiotics through the skin. Combining IR spectroscopy with an IR array detector led to the development of Fourier transform infrared (FTIR) spectroscopic imaging, which generates chemical information from different areas of a sample at the microscopic level. This is particularly important for heterogeneous samples, such as skin. Attenuated total reflectance [corrected] (ATR)-FTIR imaging has been applied to measure, in situ, the diffusion of benzyl nicotinate (BN) through the outer layer of human skin [stratum corneum (SC)]. In vitro experiments have demonstrated the heterogeneous distribution of SC surface lipids before the penetration of a saturated solution of BN. Image analysis demonstrated a strong correlation between the distribution of lipids and drugs, while ethanol appeared to be homogenously distributed in the SC. These results show the ability of ATR-FTIR imaging to measure simultaneously the affinities of drug and solvent to the lipid-rich and lipid-poor skin domains, respectively, during permeation. This information may be useful in better understanding drug-diffusion pathways through the SC." @default.
• W2120872734 created "2016-06-24" @default.
• W2120872734 creator A5029198962 @default.
• W2120872734 creator A5037567620 @default.
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• W2120872734 date "2009-01-01" @default.
• W2120872734 modified "2023-09-23" @default.
• W2120872734 title "In situ permeation study of drug through the stratum corneum using attenuated total reflection Fourier transform infrared spectroscopic imaging" @default.
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• W2120872734 doi "https://doi.org/10.1117/1.3130324" @default.
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• W2120872734 hasPublicationYear "2009" @default.
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