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- W2120883516 abstract "The standard method for the detection of disseminated epithelial tumour cells is still immunocytochemistry despite some concerns such as relative low sensitivity and subjective evaluation. Several approaches have been made to develop sensitive and specific polymerase-chain reaction assays comparable to those in use for detection of minimal residual disease in haematological malignancies. The major problem is the absence of specific genetic aberrations in solid cancer. Thus, researchers focused on amplification of so-called tissue-specific expressed genes such as epithelial structure proteins or messenger RNA of tumour markers or tumour-associated proteins. Most assays were described as highly specific valuable tools by the developers, and subsequently as non-specific by investigators. This chapter describes the mechanisms leading to so-called ‘false-positive’ and ‘false-negative’ results, and discusses the strength and weakness of RT-PCR for detection of solid cancer cells. Furthermore, strategies are discussed for development of reverse-transcriptase polymerase-chain reaction systems and for using and increasing their specificity.KeywordsClin OncolMinimal Residual DiseaseStem Cell FactorDisseminate Tumour CellCK20 mRNAThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W2120883516 created "2016-06-24" @default.
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- W2120883516 date "2005-12-30" @default.
- W2120883516 modified "2023-09-24" @default.
- W2120883516 title "Technical Aspects of the Detection of Disseminated Tumour Cells by Molecular Methods" @default.
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- W2120883516 doi "https://doi.org/10.1007/0-306-48355-6_1" @default.
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