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- W2120890050 abstract "Type 2 diabetes is a major global health problem and there is ongoing research for new treatments to manage the disease. The GLP-1R (glucagon-like peptide-1 receptor) controls the physiological response to the incretin peptide, GLP-1, and is currently a major target for the development of therapeutics owing to the broad range of potential beneficial effects in Type 2 diabetes. These include promotion of glucose-dependent insulin secretion, increased insulin biosynthesis, preservation of β-cell mass, improved peripheral insulin sensitivity and promotion of weight loss. Despite this, our understanding of GLP-1R function is still limited, with the desired spectrum of GLP-1R-mediated signalling yet to be determined. We review the current understanding of GLP-1R function, in particular, highlighting recent contributions in the field on allosteric modulation, probe-dependence and ligand-directed signal bias and how these behaviours may influence future drug development." @default.
- W2120890050 created "2016-06-24" @default.
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- W2120890050 date "2013-01-29" @default.
- W2120890050 modified "2023-09-30" @default.
- W2120890050 title "Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function" @default.
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- W2120890050 doi "https://doi.org/10.1042/bst20120236" @default.
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