FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120890400> ?p ?o ?g. }

• W2120890400 endingPage "441" @default.
• W2120890400 startingPage "433" @default.
• W2120890400 abstract "Hyperthermia has a radiosensitizing effect, which is one of the most important biological bases for its use in cancer therapy with radiation. Although the mechanism of this effect has not been clarified in molecular terms, possible involvement of either one or both of two major DNA double-strand break (DSB) repair pathways, i.e. nonhomologous end joining (NHEJ) and homologous recombination (HR), has been speculated. To test this possibility, we examined cells of the chicken B-lymphocyte cell line DT40 and its derivatives lacking NHEJ and/or HR: KU70(-/-), DNA-PKcs(-/-/-), RAD54(-/-) and KU70(-/-)/RAD54(-/-). Radiosensitization by hyperthermia could be seen in all of the mutants, including KU70(-/-)/RAD54(-/-), which lacked both NHEJ and HR. Therefore, radiosensitization by hyperthermia cannot be explained simply by its inhibitory effects, if any, on NHEJ and/or HR alone. However, in NHEJ-defective KU70(-/-) and DNA-PKcs(-/-/-), consisting of two subpopulations with distinct radiosensitivity, the radiosensitive subpopulation, which is considered to be cells in G(1) and early S, was not sensitized. Substantial sensitization was seen only in the radioresistant subpopulation, which is considered to be cells in late S and G(2), capable of repairing DSBs through HR. This observation did not exclude possible involvement of NHEJ in G(1) and early S phase and also suggested inhibitory effects of hyperthermia on HR. Thus partial contribution of NHEJ and HR in radiosensitization by hyperthermia, especially that depending on the cell cycle stage, remains to be considered." @default.
• W2120890400 created "2016-06-24" @default.
• W2120890400 creator A5015575713 @default.
• W2120890400 creator A5016934524 @default.
• W2120890400 creator A5019366369 @default.
• W2120890400 creator A5019392035 @default.
• W2120890400 creator A5019791546 @default.
• W2120890400 creator A5021977839 @default.
• W2120890400 creator A5047888069 @default.
• W2120890400 creator A5049671821 @default.
• W2120890400 creator A5050428602 @default.
• W2120890400 creator A5055656414 @default.
• W2120890400 creator A5056944762 @default.
• W2120890400 creator A5067868993 @default.
• W2120890400 creator A5068612571 @default.
• W2120890400 date "2004-10-01" @default.
• W2120890400 modified "2023-10-02" @default.
• W2120890400 title "Radiosensitization by Hyperthermia in the Chicken B-Lymphocyte Cell Line DT40 and its Derivatives Lacking Nonhomologous End Joining and/or Homologous Recombination Pathways of DNA Double-Strand Break Repair" @default.
• W2120890400 cites W111348958 @default.
• W2120890400 cites W1493910399 @default.
• W2120890400 cites W1965119945 @default.
• W2120890400 cites W1966048184 @default.
• W2120890400 cites W1969947409 @default.
• W2120890400 cites W1971708630 @default.
• W2120890400 cites W1973510010 @default.
• W2120890400 cites W1976968043 @default.
• W2120890400 cites W2002910462 @default.
• W2120890400 cites W2009347702 @default.
• W2120890400 cites W2015104103 @default.
• W2120890400 cites W2016641631 @default.
• W2120890400 cites W2017145640 @default.
• W2120890400 cites W2021635852 @default.
• W2120890400 cites W2023491022 @default.
• W2120890400 cites W2030664517 @default.
• W2120890400 cites W2032261226 @default.
• W2120890400 cites W2038492665 @default.
• W2120890400 cites W2043402257 @default.
• W2120890400 cites W2049107177 @default.
• W2120890400 cites W2053305279 @default.
• W2120890400 cites W2058800908 @default.
• W2120890400 cites W2059345576 @default.
• W2120890400 cites W2064771448 @default.
• W2120890400 cites W2065293250 @default.
• W2120890400 cites W2065572766 @default.
• W2120890400 cites W2079088689 @default.
• W2120890400 cites W2079239443 @default.
• W2120890400 cites W2085486779 @default.
• W2120890400 cites W2092049586 @default.
• W2120890400 cites W2102829314 @default.
• W2120890400 cites W2109557452 @default.
• W2120890400 cites W2109829677 @default.
• W2120890400 cites W2116511456 @default.
• W2120890400 cites W2125111752 @default.
• W2120890400 cites W2127414222 @default.
• W2120890400 cites W2128370098 @default.
• W2120890400 cites W2132538784 @default.
• W2120890400 cites W2133222493 @default.
• W2120890400 cites W2134067420 @default.
• W2120890400 cites W2142187380 @default.
• W2120890400 cites W2149779498 @default.
• W2120890400 cites W2152093387 @default.
• W2120890400 cites W2154473315 @default.
• W2120890400 cites W2154508650 @default.
• W2120890400 cites W2159076267 @default.
• W2120890400 cites W2163392106 @default.
• W2120890400 cites W2169637630 @default.
• W2120890400 cites W2177349167 @default.
• W2120890400 cites W2179960276 @default.
• W2120890400 cites W2236542555 @default.
• W2120890400 cites W2313815839 @default.
• W2120890400 cites W2318429450 @default.
• W2120890400 cites W4240461768 @default.
• W2120890400 doi "https://doi.org/10.1667/rr3239" @default.
• W2120890400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15447039" @default.
• W2120890400 hasPublicationYear "2004" @default.
• W2120890400 type Work @default.
• W2120890400 sameAs 2120890400 @default.
• W2120890400 citedByCount "19" @default.
• W2120890400 countsByYear W21208904002012 @default.
• W2120890400 countsByYear W21208904002013 @default.
• W2120890400 countsByYear W21208904002014 @default.
• W2120890400 countsByYear W21208904002015 @default.
• W2120890400 countsByYear W21208904002016 @default.
• W2120890400 countsByYear W21208904002017 @default.
• W2120890400 countsByYear W21208904002018 @default.
• W2120890400 crossrefType "journal-article" @default.
• W2120890400 hasAuthorship W2120890400A5015575713 @default.
• W2120890400 hasAuthorship W2120890400A5016934524 @default.
• W2120890400 hasAuthorship W2120890400A5019366369 @default.
• W2120890400 hasAuthorship W2120890400A5019392035 @default.
• W2120890400 hasAuthorship W2120890400A5019791546 @default.
• W2120890400 hasAuthorship W2120890400A5021977839 @default.
• W2120890400 hasAuthorship W2120890400A5047888069 @default.
• W2120890400 hasAuthorship W2120890400A5049671821 @default.
• W2120890400 hasAuthorship W2120890400A5050428602 @default.
• W2120890400 hasAuthorship W2120890400A5055656414 @default.
• W2120890400 hasAuthorship W2120890400A5056944762 @default.
• W2120890400 hasAuthorship W2120890400A5067868993 @default.

• next