FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120892437> ?p ?o ?g. }

• W2120892437 endingPage "196" @default.
• W2120892437 startingPage "188" @default.
• W2120892437 abstract "We examined the effect of mercury (Hg) associated with dental amalgam fillings on biomarkers of renal and oxidative stress in children between the ages of 5-15.5 years. Urine samples were analyzed for N-acetyl-β-D-glucosaminidase (NAG), α(1)-microglobulin (α(1)-MG), β(2)-microglobulin (β(2)-MG), retinol binding protein (RBP), albumin (ALB), 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA). The level of urinary Hg (UHg-C) was calculated as μg/g creatinine. Multiple regression analyses revealed that the excretion of urinary NAG was significantly associated with the presence of dental amalgam fillings (β=0.149, P=0.03) and the levels of UHg-C (β=0.531, P=0), with an interaction between the two (P=0). The increase in urinary NAG in relation to UHg-C levels had a dose-effect pattern. The lowest observed effect was seen at UHg-C levels above 1.452 μg/g creatinine, which is lower than previously reported. In contrast, α(1)-MG was negatively associated with the presence of dental amalgam fillings (β=-0.270, P=0), but positively with UHg-C levels (β=0.393, P=0). There were 7 children without, and one child with, dental amalgam fillings with urinary α(1)-MG levels above the reference limit of >7 mg/g creatinine. Even though α(1)-MG seems to be a reliable biomarker for early changes in renal functions, it might exert its effect only at a higher level of exposure. An inverse relationship was also observed between urinary 8-OHdG levels and the presence of dental amalgam fillings. This might suggest that the dental amalgam does not increase DNA damage but reduces the capacity to repair DNA, leading to lower urinary excretion of 8-OHdG. On the other hand, we found that Hg affected the excretion of urinary 8-OHdG in a dose-related pattern that was mostly associated with long-term exposure to low Hg levels. Urinary NAG levels were positively associated with urinary MDA levels (β=0.516, P=0) but not with 8-OHdG (β=0.134, P=0.078) after adjustment for potential confounders. Both UHg-C and the presence of dental amalgam fillings remained predictors of the NAG model. Our data provide evidence that low exposure to Hg from dental amalgam fillings exerts an effect on kidney tubular functions in children. Oxidative stress may have played a role in this mechanism. The results of this study would also suggest that urinary NAG is the most sensitive of all the investigated renal biomarkers. These results should be confirmed with further investigation." @default.
• W2120892437 created "2016-06-24" @default.
• W2120892437 creator A5065444727 @default.
• W2120892437 creator A5076564061 @default.
• W2120892437 creator A5082895427 @default.
• W2120892437 date "2012-08-01" @default.
• W2120892437 modified "2023-10-17" @default.
• W2120892437 title "Effect of mercury (Hg) dental amalgam fillings on renal and oxidative stress biomarkers in children" @default.
• W2120892437 cites W1505801879 @default.
• W2120892437 cites W1607295787 @default.
• W2120892437 cites W1968976455 @default.
• W2120892437 cites W1972922744 @default.
• W2120892437 cites W1980965029 @default.
• W2120892437 cites W1990128571 @default.
• W2120892437 cites W1991030758 @default.
• W2120892437 cites W1994660530 @default.
• W2120892437 cites W1994810477 @default.
• W2120892437 cites W1995997090 @default.
• W2120892437 cites W1998160973 @default.
• W2120892437 cites W2002583709 @default.
• W2120892437 cites W2005201861 @default.
• W2120892437 cites W2007534057 @default.
• W2120892437 cites W2012041319 @default.
• W2120892437 cites W2015457145 @default.
• W2120892437 cites W2016129011 @default.
• W2120892437 cites W2016503982 @default.
• W2120892437 cites W2020383780 @default.
• W2120892437 cites W2025380871 @default.
• W2120892437 cites W2025603365 @default.
• W2120892437 cites W2026360119 @default.
• W2120892437 cites W2026747455 @default.
• W2120892437 cites W2028343125 @default.
• W2120892437 cites W2033280206 @default.
• W2120892437 cites W2034040668 @default.
• W2120892437 cites W2036333816 @default.
• W2120892437 cites W2040711202 @default.
• W2120892437 cites W2043259160 @default.
• W2120892437 cites W2044343014 @default.
• W2120892437 cites W2047116611 @default.
• W2120892437 cites W2048468348 @default.
• W2120892437 cites W2053159099 @default.
• W2120892437 cites W2057647241 @default.
• W2120892437 cites W2061140737 @default.
• W2120892437 cites W2061563634 @default.
• W2120892437 cites W2066340690 @default.
• W2120892437 cites W2069440929 @default.
• W2120892437 cites W2069878417 @default.
• W2120892437 cites W2072946843 @default.
• W2120892437 cites W2082201644 @default.
• W2120892437 cites W2090586362 @default.
• W2120892437 cites W2092292065 @default.
• W2120892437 cites W2092567285 @default.
• W2120892437 cites W2092923406 @default.
• W2120892437 cites W2095072854 @default.
• W2120892437 cites W2103474203 @default.
• W2120892437 cites W2110894278 @default.
• W2120892437 cites W2115886467 @default.
• W2120892437 cites W2122001860 @default.
• W2120892437 cites W2122295622 @default.
• W2120892437 cites W2125219560 @default.
• W2120892437 cites W2125289626 @default.
• W2120892437 cites W2130921124 @default.
• W2120892437 cites W2131118500 @default.
• W2120892437 cites W2137527545 @default.
• W2120892437 cites W2140332754 @default.
• W2120892437 cites W2140665078 @default.
• W2120892437 cites W2150462950 @default.
• W2120892437 cites W2151540138 @default.
• W2120892437 cites W2156243205 @default.
• W2120892437 cites W2156819104 @default.
• W2120892437 cites W2159317968 @default.
• W2120892437 cites W2315774054 @default.
• W2120892437 cites W40505394 @default.
• W2120892437 cites W4246825195 @default.
• W2120892437 cites W62548840 @default.
• W2120892437 doi "https://doi.org/10.1016/j.scitotenv.2012.05.036" @default.
• W2120892437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22683759" @default.
• W2120892437 hasPublicationYear "2012" @default.
• W2120892437 type Work @default.
• W2120892437 sameAs 2120892437 @default.
• W2120892437 citedByCount "42" @default.
• W2120892437 countsByYear W21208924372013 @default.
• W2120892437 countsByYear W21208924372014 @default.
• W2120892437 countsByYear W21208924372015 @default.
• W2120892437 countsByYear W21208924372016 @default.
• W2120892437 countsByYear W21208924372017 @default.
• W2120892437 countsByYear W21208924372018 @default.
• W2120892437 countsByYear W21208924372019 @default.
• W2120892437 countsByYear W21208924372020 @default.
• W2120892437 countsByYear W21208924372022 @default.
• W2120892437 countsByYear W21208924372023 @default.
• W2120892437 crossrefType "journal-article" @default.
• W2120892437 hasAuthorship W2120892437A5065444727 @default.
• W2120892437 hasAuthorship W2120892437A5076564061 @default.
• W2120892437 hasAuthorship W2120892437A5082895427 @default.
• W2120892437 hasConcept C126322002 @default.
• W2120892437 hasConcept C134018914 @default.
• W2120892437 hasConcept C147789679 @default.

• next