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• W2120908557 abstract "Introduction: Medication of pregnant women is increasingly common in developed countries. Several placental drug transporters have been shown to transfer their substrates from the trophoblast back to the maternal circulation, thus hindering the transplacental passage of xenobiotics and protecting the fetus. However, the expression and activity of drug transporter proteins in the placenta vary during gestation and are tightly regulated by many factors. In addition, their function can be compromised by pathological conditions and/or drug–drug interactions.Areas covered: This article reviews current knowledge on placental drug transporters, their effects on placental pharmacokinetics and the regulatory mechanisms that control their expression and activity. Transcriptional, genetic and epigenetic mechanisms of placental transporter regulation and the drug–drug interactions that modulate transporter activity are described. Physiological and pathological factors that can affect drug transporter expression and function in the placenta are also discussed.Expert opinion: The expression and activity of drug transporter proteins in the placenta vary during gestation and are tightly regulated by many factors. Subsequently, there is a great variability in the expression and function of placental drug transporters both within human populations (interindividual variability) and also during gestation (intraindividual variability). An understanding of the expression and function of placental drug transporters is essential for efficient and safe therapy during pregnancy. There is clearly a need for further preclinical and clinical studies on placental drug transporters, but such investigations must be carefully designed and the resulting data should be evaluated with great caution. This review highlights several methodological aspects that will have to be considered and addressed in order to shed further light on these important issues." @default.
• W2120908557 created "2016-06-24" @default.
• W2120908557 creator A5013089143 @default.
• W2120908557 creator A5085056121 @default.
• W2120908557 date "2015-01-20" @default.
• W2120908557 modified "2023-10-10" @default.
• W2120908557 title "Regulation of drug transporter expression and function in the placenta" @default.
• W2120908557 cites W1428627388 @default.
• W2120908557 cites W1495048404 @default.
• W2120908557 cites W1537220258 @default.
• W2120908557 cites W1541826294 @default.
• W2120908557 cites W1553294146 @default.
• W2120908557 cites W1600827873 @default.
• W2120908557 cites W1866641948 @default.
• W2120908557 cites W1964063274 @default.
• W2120908557 cites W1965127293 @default.
• W2120908557 cites W1968328048 @default.
• W2120908557 cites W1969207072 @default.
• W2120908557 cites W1970218159 @default.
• W2120908557 cites W1974221464 @default.
• W2120908557 cites W1976583362 @default.
• W2120908557 cites W1977776342 @default.
• W2120908557 cites W1978092597 @default.
• W2120908557 cites W1979072037 @default.
• W2120908557 cites W1979122432 @default.
• W2120908557 cites W1979824342 @default.
• W2120908557 cites W1985834820 @default.
• W2120908557 cites W1986540119 @default.
• W2120908557 cites W1990758521 @default.
• W2120908557 cites W1990895096 @default.
• W2120908557 cites W1993662006 @default.
• W2120908557 cites W1995699866 @default.
• W2120908557 cites W1998282841 @default.
• W2120908557 cites W1998333674 @default.
• W2120908557 cites W1998517881 @default.
• W2120908557 cites W2001067238 @default.
• W2120908557 cites W2006448100 @default.
• W2120908557 cites W2007344602 @default.
• W2120908557 cites W2008596214 @default.
• W2120908557 cites W2011530842 @default.
• W2120908557 cites W2015342482 @default.
• W2120908557 cites W2019229253 @default.
• W2120908557 cites W2019572309 @default.
• W2120908557 cites W2020177737 @default.
• W2120908557 cites W2020220205 @default.
• W2120908557 cites W2021031411 @default.
• W2120908557 cites W2022892231 @default.
• W2120908557 cites W2023395206 @default.
• W2120908557 cites W2025292895 @default.
• W2120908557 cites W2027934209 @default.
• W2120908557 cites W2028890879 @default.
• W2120908557 cites W2031533902 @default.
• W2120908557 cites W2031537357 @default.
• W2120908557 cites W2032466604 @default.
• W2120908557 cites W2034886511 @default.
• W2120908557 cites W2037472613 @default.
• W2120908557 cites W2037606593 @default.
• W2120908557 cites W2037984531 @default.
• W2120908557 cites W2039877764 @default.
• W2120908557 cites W2040872150 @default.
• W2120908557 cites W2041290320 @default.
• W2120908557 cites W2042910761 @default.
• W2120908557 cites W2043730183 @default.
• W2120908557 cites W2043957781 @default.
• W2120908557 cites W2044095562 @default.
• W2120908557 cites W2045841512 @default.
• W2120908557 cites W2046923066 @default.
• W2120908557 cites W2047911553 @default.
• W2120908557 cites W2048536578 @default.
• W2120908557 cites W2049962258 @default.
• W2120908557 cites W2050312201 @default.
• W2120908557 cites W2050317717 @default.
• W2120908557 cites W2052352716 @default.
• W2120908557 cites W2052854812 @default.
• W2120908557 cites W2053510772 @default.
• W2120908557 cites W2055437362 @default.
• W2120908557 cites W2055904567 @default.
• W2120908557 cites W2057477277 @default.
• W2120908557 cites W2059536444 @default.
• W2120908557 cites W2060033529 @default.
• W2120908557 cites W2060634509 @default.
• W2120908557 cites W2061922866 @default.
• W2120908557 cites W2062701690 @default.
• W2120908557 cites W2067961925 @default.
• W2120908557 cites W2071212514 @default.
• W2120908557 cites W2071906793 @default.
• W2120908557 cites W2072525980 @default.
• W2120908557 cites W2072954867 @default.
• W2120908557 cites W2073204295 @default.
• W2120908557 cites W2073334658 @default.
• W2120908557 cites W2074803927 @default.
• W2120908557 cites W2075284437 @default.
• W2120908557 cites W2076726370 @default.
• W2120908557 cites W2079262647 @default.
• W2120908557 cites W2081378145 @default.
• W2120908557 cites W2081653475 @default.
• W2120908557 cites W2082836700 @default.
• W2120908557 cites W2083381199 @default.

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