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- W2120914837 abstract "It is established that in healthy human pregnancies, there are changes in cardiovascular status, including a significant (≈15%–20%) increase in resting heart rate.1 Although the underlying mechanisms are not well understood, it has been suggested that this pregnancy-related elevation in heart rate may be mediated by increased efferent activity of and/or sensitivity to sympathetic stimulation, concurrent with decreased sensitivity of the heart to parasympathetic activity.2 This increased sympathetic stimulation may be a reflex response to the pregnancy-related decrease in total peripheral resistance and systemic vascular tone, consistent with the need to maintain arterial blood pressure.3 The elevation in resting heart rate is usually benign, although an increase in the incidence of ventricular arrhythmias may result. At present, both intrinsic (pacemaker activity or automaticity) and extrinsic (eg, adrenergic tone) reflex responses are being considered as proarrhythmic factors; however, there is no consensus concerning the underlying ionic mechanisms.Article see p 2009In this issue of Circulation , researchers in the Fiset laboratory at the Montreal Heart Institute report that in an adult mouse model, pregnancy is associated with a significant and selective upregulation of the so-called funny current ( I f) in the sinoatrial node or primary pacemaker region of the heart.4 The term funny was coined because this current is activated by hyperpolarization, as opposed to depolarization, of membrane potential. I f is modulated, that is, increased or decreased, by the autonomic transmitters norepinephrine and acetylcholine, respectively.5 It is carried mainly by Na+ under physiological conditions.6El Khoury et al4 report that in pacemaker cells isolated from healthy pregnant adult female mice, I f is increased as a result of enhanced expression of these channels in the sarcolemma. No change in steady-state voltage dependence, that is, the range of membrane potentials for activation, …" @default.
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- W2120914837 date "2013-05-21" @default.
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- W2120914837 title "High Heart Rate in Pregnancy Is Modulated by Augmented Expression of an Ion Channel, HCN-2, in Pacemaker Tissue" @default.
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- W2120914837 doi "https://doi.org/10.1161/circulationaha.113.002760" @default.
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