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- W2120915248 abstract "Spinal and bulbar muscular atrophy (SBMA) impairs motor function in men and is linked to a CAG repeat mutation in the androgen receptor (AR) gene. Defects in motoneuronal retrograde axonal transport may critically mediate motor dysfunction in SBMA, but the site(s) where AR disrupts transport is unknown. We find deficits in retrograde labeling of spinal motoneurons in both a knock-in (KI) and a myogenic transgenic (TG) mouse model of SBMA. Likewise, live imaging of endosomal trafficking in sciatic nerve axons reveals disease-induced deficits in the flux and run length of retrogradely transported endosomes in both KI and TG males, demonstrating that disease triggered in muscle can impair retrograde transport of cargo in motoneuron axons, possibly via defective retrograde signaling. Supporting the idea of impaired retrograde signaling, we find that vascular endothelial growth factor treatment of diseased muscles reverses the transport/trafficking deficit. Transport velocity is also affected in KI males, suggesting a neurogenic component. These results demonstrate that androgens could act via both cell autonomous and non-cell autonomous mechanisms to disrupt axonal transport in motoneurons affected by SBMA." @default.
- W2120915248 created "2016-06-24" @default.
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- W2120915248 date "2011-08-26" @default.
- W2120915248 modified "2023-09-27" @default.
- W2120915248 title "Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action" @default.
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- W2120915248 cites W1931706129 @default.
- W2120915248 cites W1963128268 @default.
- W2120915248 cites W1972818610 @default.
- W2120915248 cites W1973538757 @default.
- W2120915248 cites W1975948750 @default.
- W2120915248 cites W1984355984 @default.
- W2120915248 cites W1984979116 @default.
- W2120915248 cites W2013452556 @default.
- W2120915248 cites W2013690402 @default.
- W2120915248 cites W2013820019 @default.
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- W2120915248 cites W2021132129 @default.
- W2120915248 cites W2021258666 @default.
- W2120915248 cites W2024111305 @default.
- W2120915248 cites W2025394608 @default.
- W2120915248 cites W2032211921 @default.
- W2120915248 cites W2035133362 @default.
- W2120915248 cites W2035357631 @default.
- W2120915248 cites W2036600567 @default.
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- W2120915248 doi "https://doi.org/10.1093/hmg/ddr380" @default.
- W2120915248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3196895" @default.
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