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• W2120919005 endingPage "776" @default.
• W2120919005 startingPage "756" @default.
• W2120919005 abstract "Bipolar affective disorder (manic-depressive illness) is a common, severe, chronic, and often life-threatening illness, associated with significant comorbidity. The recognition of the significant morbidity and mortality of patients with bipolar disorder, as well as the growing appreciation that a high percentage of patients respond poorly to existing treatments, has made the task of discovering new therapeutic agents, that are both efficacious and have few side effects increasingly more important. Most recent agents introduced into the pharmacopeia for the treatment of bipolar disorder have been anticonvulsants and atypical antipsychotics. We propose that novel treatments developed specifically for bipolar disorder will arise from (1) understanding more precisely the molecular mechanisms of treatments that are clearly efficacious or (2) developing medications based on the knowledge obtained of the underlying pathophysiology of bipolar disorder. Knowledge with regard to the underlying pathophysiology of bipolar disorder is increasing at a rapid pace, including alterations in intracellular signaling cascades as well as impairments of cellular plasticity and resilience in critical neuronal circuits. We propose that therapeutics designed to enhance cellular plasticity and resilience and that counter maladaptive stress-responsive systems may have considerable utility for the treatment of bipolar disorder. Therapeutic strategies designed to address cellular resilience and plasticity include the regulation of neurotrophic pathways, glucocorticoid signaling, phosphodiesterase activity, and glutamatergic throughput and mitochondrial function. While the task of developing novel medications for bipolar disorder is truly daunting, these and similar approaches will ultimately lead to better medications for the millions who suffer from this devastating illness." @default.
• W2120919005 created "2016-06-24" @default.
• W2120919005 creator A5014432936 @default.
• W2120919005 creator A5023527028 @default.
• W2120919005 creator A5037853531 @default.
• W2120919005 creator A5047437809 @default.
• W2120919005 creator A5081124023 @default.
• W2120919005 creator A5086133175 @default.
• W2120919005 date "2004-05-11" @default.
• W2120919005 modified "2023-10-14" @default.
• W2120919005 title "Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology" @default.
• W2120919005 cites W146205465 @default.
• W2120919005 cites W1509868652 @default.
• W2120919005 cites W1512847190 @default.
• W2120919005 cites W1551088980 @default.
• W2120919005 cites W1562385041 @default.
• W2120919005 cites W1572414944 @default.
• W2120919005 cites W1592665312 @default.
• W2120919005 cites W1780394705 @default.
• W2120919005 cites W1922088893 @default.
• W2120919005 cites W1944132902 @default.
• W2120919005 cites W1950744654 @default.
• W2120919005 cites W1963707665 @default.
• W2120919005 cites W1964537139 @default.
• W2120919005 cites W1964597381 @default.
• W2120919005 cites W1964970715 @default.
• W2120919005 cites W1966279131 @default.
• W2120919005 cites W1967122944 @default.
• W2120919005 cites W1968302953 @default.
• W2120919005 cites W1968533747 @default.
• W2120919005 cites W1968840823 @default.
• W2120919005 cites W1969392677 @default.
• W2120919005 cites W1969819088 @default.
• W2120919005 cites W1969852349 @default.
• W2120919005 cites W1970625707 @default.
• W2120919005 cites W1975218744 @default.
• W2120919005 cites W1977977170 @default.
• W2120919005 cites W1978157729 @default.
• W2120919005 cites W1978217907 @default.
• W2120919005 cites W1980630337 @default.
• W2120919005 cites W1981957263 @default.
• W2120919005 cites W1983568884 @default.
• W2120919005 cites W1983664266 @default.
• W2120919005 cites W1983914274 @default.
• W2120919005 cites W1984931082 @default.
• W2120919005 cites W1984992452 @default.
• W2120919005 cites W1985974491 @default.
• W2120919005 cites W1987528796 @default.
• W2120919005 cites W1988244113 @default.
• W2120919005 cites W1988957190 @default.
• W2120919005 cites W1991542726 @default.
• W2120919005 cites W1991891142 @default.
• W2120919005 cites W1994109837 @default.
• W2120919005 cites W1995188451 @default.
• W2120919005 cites W1995671210 @default.
• W2120919005 cites W1998934862 @default.
• W2120919005 cites W2000300447 @default.
• W2120919005 cites W2003432290 @default.
• W2120919005 cites W2004519140 @default.
• W2120919005 cites W2005817345 @default.
• W2120919005 cites W2006261940 @default.
• W2120919005 cites W2008162127 @default.
• W2120919005 cites W2008219652 @default.
• W2120919005 cites W2008291494 @default.
• W2120919005 cites W2008671190 @default.
• W2120919005 cites W2009058487 @default.
• W2120919005 cites W2009772232 @default.
• W2120919005 cites W2010910086 @default.
• W2120919005 cites W2012698812 @default.
• W2120919005 cites W2016713681 @default.
• W2120919005 cites W2017192748 @default.
• W2120919005 cites W2017523345 @default.
• W2120919005 cites W2019806256 @default.
• W2120919005 cites W2020245695 @default.
• W2120919005 cites W2020461481 @default.
• W2120919005 cites W2020789218 @default.
• W2120919005 cites W2020897240 @default.
• W2120919005 cites W2021069714 @default.
• W2120919005 cites W2022290338 @default.
• W2120919005 cites W2022700331 @default.
• W2120919005 cites W2022984493 @default.
• W2120919005 cites W2023081218 @default.
• W2120919005 cites W2023243943 @default.
• W2120919005 cites W2023554569 @default.
• W2120919005 cites W2024105385 @default.
• W2120919005 cites W2025468569 @default.
• W2120919005 cites W2026412461 @default.
• W2120919005 cites W2027266498 @default.
• W2120919005 cites W2028153427 @default.
• W2120919005 cites W2029184215 @default.
• W2120919005 cites W2029691379 @default.
• W2120919005 cites W2030249389 @default.
• W2120919005 cites W2030928752 @default.
• W2120919005 cites W2033345750 @default.
• W2120919005 cites W2034908919 @default.
• W2120919005 cites W2035000328 @default.
• W2120919005 cites W2037231243 @default.
• W2120919005 cites W2037253428 @default.

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