FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120932103> ?p ?o ?g. }

• W2120932103 endingPage "884" @default.
• W2120932103 startingPage "871" @default.
• W2120932103 abstract "Abstract There is increasing recognition that genetic diversity can affect the spread of diseases, potentially affecting plant and livestock disease control as well as the emergence of human disease outbreaks. Nevertheless, even though computational tools can guide the control of infectious diseases, few epidemiological models can simultaneously accommodate the inherent individual heterogeneity in multiple infectious disease traits influencing disease transmission, such as the frequently modeled propensity to become infected and infectivity, which describes the host ability to transmit the infection to susceptible individuals. Furthermore, current quantitative genetic models fail to fully capture the heritable variation in host infectivity, mainly because they cannot accommodate the nonlinear infection dynamics underlying epidemiological data. We present in this article a novel statistical model and an inference method to estimate genetic parameters associated with both host susceptibility and infectivity. Our methodology combines quantitative genetic models of social interactions with stochastic processes to model the random, nonlinear, and dynamic nature of infections and uses adaptive Bayesian computational techniques to estimate the model parameters. Results using simulated epidemic data show that our model can accurately estimate heritabilities and genetic risks not only of susceptibility but also of infectivity, therefore exploring a trait whose heritable variation is currently ignored in disease genetics and can greatly influence the spread of infectious diseases. Our proposed methodology offers potential impacts in areas such as livestock disease control through selective breeding and also in predicting and controlling the emergence of disease outbreaks in human populations." @default.
• W2120932103 created "2016-06-24" @default.
• W2120932103 creator A5006142699 @default.
• W2120932103 creator A5026121852 @default.
• W2120932103 creator A5044315814 @default.
• W2120932103 creator A5049314246 @default.
• W2120932103 creator A5067576037 @default.
• W2120932103 date "2015-09-23" @default.
• W2120932103 modified "2023-10-14" @default.
• W2120932103 title "A Novel Statistical Model to Estimate Host Genetic Effects Affecting Disease Transmission" @default.
• W2120932103 cites W1568090966 @default.
• W2120932103 cites W1883683135 @default.
• W2120932103 cites W1985739089 @default.
• W2120932103 cites W1990192858 @default.
• W2120932103 cites W1991071535 @default.
• W2120932103 cites W1995972977 @default.
• W2120932103 cites W1997930486 @default.
• W2120932103 cites W2024702568 @default.
• W2120932103 cites W2024749530 @default.
• W2120932103 cites W2032615295 @default.
• W2120932103 cites W2035636354 @default.
• W2120932103 cites W2047735621 @default.
• W2120932103 cites W2047978125 @default.
• W2120932103 cites W2049144280 @default.
• W2120932103 cites W2056052741 @default.
• W2120932103 cites W2063329307 @default.
• W2120932103 cites W2069251911 @default.
• W2120932103 cites W2087712795 @default.
• W2120932103 cites W2089453318 @default.
• W2120932103 cites W2090556607 @default.
• W2120932103 cites W2091207266 @default.
• W2120932103 cites W2097782419 @default.
• W2120932103 cites W2102251205 @default.
• W2120932103 cites W2102694845 @default.
• W2120932103 cites W2107282357 @default.
• W2120932103 cites W2111566225 @default.
• W2120932103 cites W2111689250 @default.
• W2120932103 cites W2115952427 @default.
• W2120932103 cites W2118726788 @default.
• W2120932103 cites W2118917960 @default.
• W2120932103 cites W2121917753 @default.
• W2120932103 cites W2132362070 @default.
• W2120932103 cites W2136037152 @default.
• W2120932103 cites W2136163227 @default.
• W2120932103 cites W2139354194 @default.
• W2120932103 cites W2144877393 @default.
• W2120932103 cites W2149952308 @default.
• W2120932103 cites W2152977846 @default.
• W2120932103 cites W2155418451 @default.
• W2120932103 cites W2159987055 @default.
• W2120932103 cites W2161469887 @default.
• W2120932103 cites W2165055537 @default.
• W2120932103 cites W2168122182 @default.
• W2120932103 cites W2172174796 @default.
• W2120932103 cites W3100351146 @default.
• W2120932103 cites W321407880 @default.
• W2120932103 cites W98559660 @default.
• W2120932103 doi "https://doi.org/10.1534/genetics.115.179853" @default.
• W2120932103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4649657" @default.
• W2120932103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26405030" @default.
• W2120932103 hasPublicationYear "2015" @default.
• W2120932103 type Work @default.
• W2120932103 sameAs 2120932103 @default.
• W2120932103 citedByCount "29" @default.
• W2120932103 countsByYear W21209321032016 @default.
• W2120932103 countsByYear W21209321032017 @default.
• W2120932103 countsByYear W21209321032018 @default.
• W2120932103 countsByYear W21209321032019 @default.
• W2120932103 countsByYear W21209321032020 @default.
• W2120932103 countsByYear W21209321032021 @default.
• W2120932103 countsByYear W21209321032022 @default.
• W2120932103 crossrefType "journal-article" @default.
• W2120932103 hasAuthorship W2120932103A5006142699 @default.
• W2120932103 hasAuthorship W2120932103A5026121852 @default.
• W2120932103 hasAuthorship W2120932103A5044315814 @default.
• W2120932103 hasAuthorship W2120932103A5049314246 @default.
• W2120932103 hasAuthorship W2120932103A5067576037 @default.
• W2120932103 hasBestOaLocation W21209321031 @default.
• W2120932103 hasConcept C106358424 @default.
• W2120932103 hasConcept C116675565 @default.
• W2120932103 hasConcept C126831891 @default.
• W2120932103 hasConcept C142724271 @default.
• W2120932103 hasConcept C154945302 @default.
• W2120932103 hasConcept C159047783 @default.
• W2120932103 hasConcept C2522874641 @default.
• W2120932103 hasConcept C2776214188 @default.
• W2120932103 hasConcept C2779134260 @default.
• W2120932103 hasConcept C41008148 @default.
• W2120932103 hasConcept C524204448 @default.
• W2120932103 hasConcept C54355233 @default.
• W2120932103 hasConcept C71924100 @default.
• W2120932103 hasConcept C761482 @default.
• W2120932103 hasConcept C76155785 @default.
• W2120932103 hasConcept C86803240 @default.
• W2120932103 hasConceptScore W2120932103C106358424 @default.
• W2120932103 hasConceptScore W2120932103C116675565 @default.
• W2120932103 hasConceptScore W2120932103C126831891 @default.
• W2120932103 hasConceptScore W2120932103C142724271 @default.

• next