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• W2120940100 abstract "A laboratory model of total electrocardiographic alternation has been developed which consists of an excised, perfused rabbit heart contained in a 6.35 cm diameter fluid-filled spherical chamber. Under these conditions in about a fourth of spontaneously beating hearts bistable (“flip-flop”) movements will develop that lock in with the heartbeat. Computer-processed signals derived from 20 evenly distributed surface electrodes showed total electrocardiographic alternation during such periods. Swinging angular movements of the oscillating heart tended to be quite vigorous and could amount to 50 or 60 °. Torsional rotations of up to 35 ° about the vertical axis were also recorded. Two previously unreported cases of electrical alternans associated with massive pericardial effusion are briefly described and interpreted in the light of the experimental observations. The study supports the “anatomic rotation hypothesis” of total alternans. The concept of critical cardiac compression as an important accessory factor may yet apply to some clinical cases although it appears to serve no role in the experimental model. A simple mechanistic hypothesis is offered to explain the anatomic rotation that occurred both in this model and in a few reported cases." @default.
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• W2120940100 date "1973-02-01" @default.
• W2120940100 modified "2023-09-27" @default.
• W2120940100 title "Experimental and clinical aspects of total electrocardiographic alternation" @default.
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• W2120940100 doi "https://doi.org/10.1016/0002-9149(73)91038-2" @default.
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