FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120965577> ?p ?o ?g. }

• W2120965577 endingPage "25" @default.
• W2120965577 startingPage "1" @default.
• W2120965577 abstract "A literature review covering the last 14 yr has been performed in the field of combination toxicology and human risk assessment from exposure to chemical mixtures, with special emphasis on mixtures of pesticides at low doses, that is, at levels likely to occur in human diet and environment. Despite a large body of knowledge in the field of risk assessment methodologies for exposure to chemical and pesticide mixtures, there is no single methodological approach in combination toxicology and health risk assessment of chemical mixtures, and therefore professional judgment is still required. Generally, the dose or response additivity approach that may be applied to evaluate potential risk for chemical mixtures in human toxicology overestimates the risk of a combination of chemicals. The recent endocrine disrupter issue demonstrated the difficulty of reproducibility of data when testing environmental toxicants at very low levels, and the need for more basic work in this field. The use of integrated methodological approaches may provide more reliable predictive data in the risk assessment of chemical mixtures in future. Yet data have demonstrated that exposure to a combination of compounds does not cause effects stronger than the ones of their most active component, provided components are present at low concentration levels, like acceptable daily intake (ADI) or reference dose (RfD) levels, well below their respective no-observed-adverse-effect levels (NOAELs). Although it has been demonstrated that a combination of compounds with the same target organ and the same or very similar mechanisms of action may cause additive or synergistic effects, the chance of such effects will most likely diminish with decreasing exposure levels to such combinations. Synergism and antagonism may both occur at the same time at different organs or targets in the same organism. However, and despite some exceptions, it has been demonstrated that interaction between components is not a common event at low levels of human exposure such as those that may occur through pesticides residues in food or drinking water. The introduction of a special safety factor as a standard for mixtures in addition to those normally used for deriving ADIs, RfDs, or minimal risk levels is not supported by data. It can be concluded from our review that, as a general rule, exposure to mixtures of pesticides at low doses of the individual constituents does not represent a potential source of concern to human health." @default.
• W2120965577 created "2016-06-24" @default.
• W2120965577 creator A5070207360 @default.
• W2120965577 date "2000-01-01" @default.
• W2120965577 modified "2023-10-15" @default.
• W2120965577 title "HEALTH RISK OF LOW-DOSE PESTICIDES MIXTURES: A Review of the 1985-1998 Literature On Combination Toxicology and Health Risk Assessment" @default.
• W2120965577 cites W105940909 @default.
• W2120965577 cites W1598506317 @default.
• W2120965577 cites W1964606945 @default.
• W2120965577 cites W1966297374 @default.
• W2120965577 cites W1973176092 @default.
• W2120965577 cites W1973236325 @default.
• W2120965577 cites W1975506426 @default.
• W2120965577 cites W1979503106 @default.
• W2120965577 cites W1991996974 @default.
• W2120965577 cites W1995668218 @default.
• W2120965577 cites W2001883095 @default.
• W2120965577 cites W2002021255 @default.
• W2120965577 cites W2003175312 @default.
• W2120965577 cites W2012288255 @default.
• W2120965577 cites W2019001895 @default.
• W2120965577 cites W2019984392 @default.
• W2120965577 cites W2030421495 @default.
• W2120965577 cites W2035069387 @default.
• W2120965577 cites W2037748044 @default.
• W2120965577 cites W2042769915 @default.
• W2120965577 cites W2043768549 @default.
• W2120965577 cites W2047640665 @default.
• W2120965577 cites W2050902048 @default.
• W2120965577 cites W2061477117 @default.
• W2120965577 cites W2067336631 @default.
• W2120965577 cites W2070285360 @default.
• W2120965577 cites W2072753444 @default.
• W2120965577 cites W2075240587 @default.
• W2120965577 cites W2077245412 @default.
• W2120965577 cites W2077724086 @default.
• W2120965577 cites W2079316501 @default.
• W2120965577 cites W2081094011 @default.
• W2120965577 cites W2084595765 @default.
• W2120965577 cites W2089082755 @default.
• W2120965577 cites W2120168333 @default.
• W2120965577 cites W2155664391 @default.
• W2120965577 cites W2156493454 @default.
• W2120965577 cites W2322361341 @default.
• W2120965577 cites W2442440549 @default.
• W2120965577 cites W2484636948 @default.
• W2120965577 cites W2485395569 @default.
• W2120965577 cites W2488712353 @default.
• W2120965577 doi "https://doi.org/10.1080/109374000281122" @default.
• W2120965577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10711323" @default.
• W2120965577 hasPublicationYear "2000" @default.
• W2120965577 type Work @default.
• W2120965577 sameAs 2120965577 @default.
• W2120965577 citedByCount "69" @default.
• W2120965577 countsByYear W21209655772012 @default.
• W2120965577 countsByYear W21209655772013 @default.
• W2120965577 countsByYear W21209655772014 @default.
• W2120965577 countsByYear W21209655772016 @default.
• W2120965577 countsByYear W21209655772017 @default.
• W2120965577 countsByYear W21209655772018 @default.
• W2120965577 countsByYear W21209655772020 @default.
• W2120965577 countsByYear W21209655772021 @default.
• W2120965577 countsByYear W21209655772022 @default.
• W2120965577 countsByYear W21209655772023 @default.
• W2120965577 crossrefType "journal-article" @default.
• W2120965577 hasAuthorship W2120965577A5070207360 @default.
• W2120965577 hasConcept C112930515 @default.
• W2120965577 hasConcept C12174686 @default.
• W2120965577 hasConcept C126322002 @default.
• W2120965577 hasConcept C161176658 @default.
• W2120965577 hasConcept C198408306 @default.
• W2120965577 hasConcept C2779794483 @default.
• W2120965577 hasConcept C2780373086 @default.
• W2120965577 hasConcept C29730261 @default.
• W2120965577 hasConcept C2987857752 @default.
• W2120965577 hasConcept C33070731 @default.
• W2120965577 hasConcept C38652104 @default.
• W2120965577 hasConcept C41008148 @default.
• W2120965577 hasConcept C6557445 @default.
• W2120965577 hasConcept C71924100 @default.
• W2120965577 hasConcept C86803240 @default.
• W2120965577 hasConcept C99454951 @default.
• W2120965577 hasConceptScore W2120965577C112930515 @default.
• W2120965577 hasConceptScore W2120965577C12174686 @default.
• W2120965577 hasConceptScore W2120965577C126322002 @default.
• W2120965577 hasConceptScore W2120965577C161176658 @default.
• W2120965577 hasConceptScore W2120965577C198408306 @default.
• W2120965577 hasConceptScore W2120965577C2779794483 @default.
• W2120965577 hasConceptScore W2120965577C2780373086 @default.
• W2120965577 hasConceptScore W2120965577C29730261 @default.
• W2120965577 hasConceptScore W2120965577C2987857752 @default.
• W2120965577 hasConceptScore W2120965577C33070731 @default.
• W2120965577 hasConceptScore W2120965577C38652104 @default.
• W2120965577 hasConceptScore W2120965577C41008148 @default.
• W2120965577 hasConceptScore W2120965577C6557445 @default.
• W2120965577 hasConceptScore W2120965577C71924100 @default.
• W2120965577 hasConceptScore W2120965577C86803240 @default.
• W2120965577 hasConceptScore W2120965577C99454951 @default.

• next