FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120981128> ?p ?o ?g. }

• W2120981128 endingPage "452" @default.
• W2120981128 startingPage "443" @default.
• W2120981128 abstract "Kinetoplastid parasites exhibit a rich and diverse biology which mirrors many of the most interesting topics of current interest and study in the broader biological sciences. These evolutionarily ancient organisms possess intriguing mechanisms for control of gene expression, and exhibit complex patterns of cell morphogenesis orchestrated by an internal cytoskeleton. Their cell shapes change during a set of complex cell type differentiations in their life cycles. These differentiations are intimately linked to interactions with mammalian hosts or insect vectors, and often, these differentiations appear central to the successful transfer of the parasite between vector and host, and host and vector. The basics of this rich and complex cell and life cycle biology were described (with often rather forgotten clarity and prescience) in the early period of the last century. The last 30 years have seen major developments in our understanding of this biology. Ultrastructural differences in the various cells of the life cycle stages of Trypanosoma brucei, Trypanosoma cruzi and the various Leishmania species have been documented, and such studies have proven highly informative in defining important aspects of parasite adaptation. They have also proven to be a rich source of information for defining unusual aspects of parasite cell biology, novel organelles and cell architecture. This ultrastructural cell biology has been mirrored in a set of biochemical explanations defining unusual aspects of metabolism, surface molecules, and organelles. Finally, the application of molecular biology to these parasites revealed fascinating layers of complexity in the control of gene expression. These molecular studies have given us particular insights into polycistronic transcription, trans-splicing, RNA editing and gene rearrangements during antigenic variation. In contrast to other microbial systems, these cell biological, biochemical and molecular studies have not been greatly aided by insights gained from genetics – the diploid nature of the genome has discouraged the application of selectional genetics, mutant isolation and analysis. This is an important fact, since in general, it means that we have only recently started to analyse the phenotypes of mutants produced in the context of reverse genetics. In the following, I will argue that this lack of investment in the analysis of mutant phenotype is just one of the challenges that will need to be met if we are to gain the expected added value from the parasite genome projects. In this presentation, I will use some of the current areas of interest in the biology of T. brucei, T. cruzi and the Leishmania species to rehearse some of the insights and challenges that are likely to stem from the application of genomics and post-genomic studies to the kinetoplastid parasites. In some cases, I will exemplify points by illustrations from my laboratory's work, interests and hypotheses. The presentation slants therefore towards T. brucei biology, however, in each case the reader will, no doubt, see the generalities of application to other kinetoplastid parasites." @default.
• W2120981128 created "2016-06-24" @default.
• W2120981128 creator A5027929813 @default.
• W2120981128 date "2001-05-01" @default.
• W2120981128 modified "2023-10-03" @default.
• W2120981128 title "The biology of kinetoplastid parasites: insights and challenges from genomics and post-genomics" @default.
• W2120981128 cites W1485500114 @default.
• W2120981128 cites W1856709472 @default.
• W2120981128 cites W1907440158 @default.
• W2120981128 cites W1966752200 @default.
• W2120981128 cites W1969256416 @default.
• W2120981128 cites W1973541545 @default.
• W2120981128 cites W1976484209 @default.
• W2120981128 cites W1981259240 @default.
• W2120981128 cites W2006100734 @default.
• W2120981128 cites W2008917555 @default.
• W2120981128 cites W2009866838 @default.
• W2120981128 cites W2010724015 @default.
• W2120981128 cites W2014565441 @default.
• W2120981128 cites W2034369933 @default.
• W2120981128 cites W2037755199 @default.
• W2120981128 cites W2042981013 @default.
• W2120981128 cites W2043629407 @default.
• W2120981128 cites W2050885009 @default.
• W2120981128 cites W2056012735 @default.
• W2120981128 cites W2058943343 @default.
• W2120981128 cites W2077489356 @default.
• W2120981128 cites W2084813999 @default.
• W2120981128 cites W2099577129 @default.
• W2120981128 cites W2104478124 @default.
• W2120981128 cites W2112312839 @default.
• W2120981128 cites W2113447712 @default.
• W2120981128 cites W2117626458 @default.
• W2120981128 cites W2125183835 @default.
• W2120981128 cites W2128041433 @default.
• W2120981128 cites W2134850931 @default.
• W2120981128 cites W2149108381 @default.
• W2120981128 cites W2151592139 @default.
• W2120981128 cites W2153992958 @default.
• W2120981128 cites W2185793396 @default.
• W2120981128 doi "https://doi.org/10.1016/s0020-7519(01)00154-0" @default.
• W2120981128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11334928" @default.
• W2120981128 hasPublicationYear "2001" @default.
• W2120981128 type Work @default.
• W2120981128 sameAs 2120981128 @default.
• W2120981128 citedByCount "56" @default.
• W2120981128 countsByYear W21209811282012 @default.
• W2120981128 countsByYear W21209811282013 @default.
• W2120981128 countsByYear W21209811282014 @default.
• W2120981128 countsByYear W21209811282015 @default.
• W2120981128 countsByYear W21209811282016 @default.
• W2120981128 countsByYear W21209811282018 @default.
• W2120981128 countsByYear W21209811282019 @default.
• W2120981128 countsByYear W21209811282021 @default.
• W2120981128 countsByYear W21209811282022 @default.
• W2120981128 countsByYear W21209811282023 @default.
• W2120981128 crossrefType "journal-article" @default.
• W2120981128 hasAuthorship W2120981128A5027929813 @default.
• W2120981128 hasConcept C104317684 @default.
• W2120981128 hasConcept C141231307 @default.
• W2120981128 hasConcept C168240541 @default.
• W2120981128 hasConcept C183074962 @default.
• W2120981128 hasConcept C189206191 @default.
• W2120981128 hasConcept C54355233 @default.
• W2120981128 hasConcept C70721500 @default.
• W2120981128 hasConcept C78458016 @default.
• W2120981128 hasConcept C86803240 @default.
• W2120981128 hasConceptScore W2120981128C104317684 @default.
• W2120981128 hasConceptScore W2120981128C141231307 @default.
• W2120981128 hasConceptScore W2120981128C168240541 @default.
• W2120981128 hasConceptScore W2120981128C183074962 @default.
• W2120981128 hasConceptScore W2120981128C189206191 @default.
• W2120981128 hasConceptScore W2120981128C54355233 @default.
• W2120981128 hasConceptScore W2120981128C70721500 @default.
• W2120981128 hasConceptScore W2120981128C78458016 @default.
• W2120981128 hasConceptScore W2120981128C86803240 @default.
• W2120981128 hasIssue "5-6" @default.
• W2120981128 hasLocation W21209811281 @default.
• W2120981128 hasLocation W21209811282 @default.
• W2120981128 hasOpenAccess W2120981128 @default.
• W2120981128 hasPrimaryLocation W21209811281 @default.
• W2120981128 hasRelatedWork W2018943483 @default.
• W2120981128 hasRelatedWork W2024280449 @default.
• W2120981128 hasRelatedWork W2046781332 @default.
• W2120981128 hasRelatedWork W2077581525 @default.
• W2120981128 hasRelatedWork W2752705313 @default.
• W2120981128 hasRelatedWork W3147998005 @default.
• W2120981128 hasRelatedWork W4242167427 @default.
• W2120981128 hasRelatedWork W424511966 @default.
• W2120981128 hasRelatedWork W437141911 @default.
• W2120981128 hasRelatedWork W566690110 @default.
• W2120981128 hasVolume "31" @default.
• W2120981128 isParatext "false" @default.
• W2120981128 isRetracted "false" @default.
• W2120981128 magId "2120981128" @default.
• W2120981128 workType "article" @default.