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- W2120996848 abstract "In these studies, we compare the efficacy of two new azole antifungals with fluconazole in a murine model of cryptococcal meningitis. Mice were infected intracranially. Beginning one day later, groups of 7-10 mice were treated through to day 10 orally with UR-9751 or UR-9746 at 0.1, 0.25, 0.5, 1 or 10 mg kg(-1) day(-1) or fluconazole at 10 mg kg(-1) day(-1). At 10 mg kg(-1) day(-1), all three drugs prolonged survival over controls, but at 1 mg kg(-1) day(-1) only UR-9746 prolonged survival. Tissue counts were more varied on mice sacrificed 8 days after infection. In general, both UR drugs were equal or more potent than fluconazole, and UR-9751 was more effective than UR-9746." @default.
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- W2120996848 date "2000-01-01" @default.
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- W2120996848 title "Treatment of murine cryptococcal meningitis with UR-9751 and UR-9746" @default.
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- W2120996848 doi "https://doi.org/10.1080/mmy.38.3.221.224" @default.
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