FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121004093> ?p ?o ?g. }

• W2121004093 endingPage "165" @default.
• W2121004093 startingPage "156" @default.
• W2121004093 abstract "Background. A predominantly T-helper type 2 (Th2) immune response is critical in the prognosis of pulmonary Pseudomonas aeruginosa infection. But the mucosal and systemic immune responses can be influenced by the intestinal microbiota. Methods. We assessed the effect of microbiota compositional changes induced by a diet enriched in 5% acidic oligosaccharides derived from pectin (pAOS) on the immune response and outcome of chronic pulmonary P. aeruginosa infection in mice. Results. pAOS promoted Th1 polarization by increasing interferon γ release, upregulating t-bet gene expression, decreasing interleukin 4 secretion, and downregulating gata3 gene expression. pAOS also sustained the release of keratinocyte chemoattractant, recruited polynuclear leukocytes and macrophages, stimulated M1 macrophage activation and interleukin 10 release, and decreased tumor necrosis factor α release in the lung. These effects led to increased bacterial clearance after the first and second P. aeruginosa infections. pAOS modified the intestinal microbiota by stimulating the growth of species involved in immunity development, such as Bifidobacterium species, Sutturella wadsworthia, and Clostridium cluster XIVa organisms, and at the same time increased the production of butyrate and propionate. Conclusion. These results suggest that pAOS may have beneficial effects by limiting the number and severity of pulmonary exacerbations in patients chronically infected with P. aeruginosa, such as individuals with cystic fibrosis." @default.
• W2121004093 created "2016-06-24" @default.
• W2121004093 creator A5002748427 @default.
• W2121004093 creator A5022296872 @default.
• W2121004093 creator A5032471444 @default.
• W2121004093 creator A5032799892 @default.
• W2121004093 creator A5034643275 @default.
• W2121004093 creator A5052817718 @default.
• W2121004093 creator A5066843507 @default.
• W2121004093 creator A5067535218 @default.
• W2121004093 creator A5081915960 @default.
• W2121004093 date "2014-08-19" @default.
• W2121004093 modified "2023-10-03" @default.
• W2121004093 title "Dietary Pectin–Derived Acidic Oligosaccharides Improve the Pulmonary Bacterial Clearance of<i>Pseudomonas aeruginosa</i>Lung Infection in Mice by Modulating Intestinal Microbiota and Immunity" @default.
• W2121004093 cites W1526240962 @default.
• W2121004093 cites W1567514429 @default.
• W2121004093 cites W1601949239 @default.
• W2121004093 cites W1831301545 @default.
• W2121004093 cites W1832400618 @default.
• W2121004093 cites W1863631349 @default.
• W2121004093 cites W1972321346 @default.
• W2121004093 cites W1972654494 @default.
• W2121004093 cites W1983845888 @default.
• W2121004093 cites W1992144919 @default.
• W2121004093 cites W1995801005 @default.
• W2121004093 cites W2002941870 @default.
• W2121004093 cites W2009759079 @default.
• W2121004093 cites W2009917983 @default.
• W2121004093 cites W2022483534 @default.
• W2121004093 cites W2023516396 @default.
• W2121004093 cites W2033193754 @default.
• W2121004093 cites W2038095190 @default.
• W2121004093 cites W2038130397 @default.
• W2121004093 cites W2039892708 @default.
• W2121004093 cites W2043138882 @default.
• W2121004093 cites W2049715421 @default.
• W2121004093 cites W2050872483 @default.
• W2121004093 cites W2060185417 @default.
• W2121004093 cites W2066484939 @default.
• W2121004093 cites W2067524407 @default.
• W2121004093 cites W2073809390 @default.
• W2121004093 cites W2076307872 @default.
• W2121004093 cites W2078929498 @default.
• W2121004093 cites W2082578477 @default.
• W2121004093 cites W2083979121 @default.
• W2121004093 cites W2091900324 @default.
• W2121004093 cites W2093829386 @default.
• W2121004093 cites W2101779729 @default.
• W2121004093 cites W2109832621 @default.
• W2121004093 cites W2110115544 @default.
• W2121004093 cites W2112902381 @default.
• W2121004093 cites W2115407784 @default.
• W2121004093 cites W2121676188 @default.
• W2121004093 cites W2129049897 @default.
• W2121004093 cites W2135735447 @default.
• W2121004093 cites W2150326634 @default.
• W2121004093 cites W2150968312 @default.
• W2121004093 cites W2151798187 @default.
• W2121004093 cites W2157800726 @default.
• W2121004093 cites W2164386968 @default.
• W2121004093 doi "https://doi.org/10.1093/infdis/jiu391" @default.
• W2121004093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25139019" @default.
• W2121004093 hasPublicationYear "2014" @default.
• W2121004093 type Work @default.
• W2121004093 sameAs 2121004093 @default.
• W2121004093 citedByCount "42" @default.
• W2121004093 countsByYear W21210040932015 @default.
• W2121004093 countsByYear W21210040932016 @default.
• W2121004093 countsByYear W21210040932017 @default.
• W2121004093 countsByYear W21210040932018 @default.
• W2121004093 countsByYear W21210040932019 @default.
• W2121004093 countsByYear W21210040932020 @default.
• W2121004093 countsByYear W21210040932021 @default.
• W2121004093 countsByYear W21210040932022 @default.
• W2121004093 countsByYear W21210040932023 @default.
• W2121004093 crossrefType "journal-article" @default.
• W2121004093 hasAuthorship W2121004093A5002748427 @default.
• W2121004093 hasAuthorship W2121004093A5022296872 @default.
• W2121004093 hasAuthorship W2121004093A5032471444 @default.
• W2121004093 hasAuthorship W2121004093A5032799892 @default.
• W2121004093 hasAuthorship W2121004093A5034643275 @default.
• W2121004093 hasAuthorship W2121004093A5052817718 @default.
• W2121004093 hasAuthorship W2121004093A5066843507 @default.
• W2121004093 hasAuthorship W2121004093A5067535218 @default.
• W2121004093 hasAuthorship W2121004093A5081915960 @default.
• W2121004093 hasBestOaLocation W21210040931 @default.
• W2121004093 hasConcept C100544194 @default.
• W2121004093 hasConcept C17991360 @default.
• W2121004093 hasConcept C203014093 @default.
• W2121004093 hasConcept C2776979534 @default.
• W2121004093 hasConcept C2777637488 @default.
• W2121004093 hasConcept C2780206646 @default.
• W2121004093 hasConcept C2780305828 @default.
• W2121004093 hasConcept C523546767 @default.
• W2121004093 hasConcept C54355233 @default.
• W2121004093 hasConcept C55493867 @default.
• W2121004093 hasConcept C86803240 @default.
• W2121004093 hasConcept C8891405 @default.

• next