FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121008097> ?p ?o ?g. }

• W2121008097 endingPage "996" @default.
• W2121008097 startingPage "988" @default.
• W2121008097 abstract "Rationale: Quantitative computed tomography (CT) has been used to phenotype patients with chronic obstructive pulmonary disease (COPD). A mixed phenotype is defined as the presence of both airway wall thickening and emphysema on quantitative CT. Little is known about patients with COPD with the mixed phenotype.Objectives: To propose a method of phenotyping COPD based on quantitative CT and to compare clinically relevant outcomes between patients with COPD with the mixed phenotype and those with other CT-based phenotypes.Methods: Each of 427 male smokers (187 without COPD, 240 with COPD) underwent a complete medical interview, pulmonary function testing, and whole-lung CT on the same day. The percentage of low-attenuation volume at the threshold of −950 Hounsfield units (%LAV) and the square root of wall area of a hypothetical airway with an internal perimeter of 10 mm (Pi10) were measured. Patients with COPD were classified into four distinct phenotypes based on the upper limits of normal for %LAV and Pi10, which were derived from the data of smokers without COPD by using quantile regression.Measurements and Main Results: Of 240 patients with COPD, 52 (21.7%) were classified as CT-normal phenotype, 39 (16.3%) as airway-dominant phenotype, 103 (42.9%) as emphysema-dominant phenotype, and 46 (19.2%) as mixed phenotype. Patients with COPD with the mixed phenotype were associated with more severe dyspnea than those with each of the remaining CT-based phenotypes (P < 0.01 for all comparisons). The number of hospitalizations for COPD exacerbations during the preceding year was 2.0 to 3.6 times higher in patients with the mixed phenotype than in those with each of the remaining CT-based phenotypes (P < 0.05 for all comparisons). Findings persisted after adjustment for age, pack-years of smoking, smoking status, body mass index, and FEV1.Conclusions: Patients with COPD with the mixed phenotype are associated with more severe dyspnea and more frequent hospitalizations than those with each of the remaining CT-based phenotypes. Thus, patients with COPD with the mixed phenotype may need more attention and interventions." @default.
• W2121008097 created "2016-06-24" @default.
• W2121008097 creator A5003913659 @default.
• W2121008097 creator A5006616360 @default.
• W2121008097 creator A5009383534 @default.
• W2121008097 creator A5014772441 @default.
• W2121008097 creator A5020071687 @default.
• W2121008097 creator A5034085198 @default.
• W2121008097 creator A5039052833 @default.
• W2121008097 creator A5058795367 @default.
• W2121008097 creator A5059309177 @default.
• W2121008097 creator A5059646510 @default.
• W2121008097 creator A5063352775 @default.
• W2121008097 creator A5068191768 @default.
• W2121008097 creator A5071650875 @default.
• W2121008097 creator A5079144383 @default.
• W2121008097 creator A5085036473 @default.
• W2121008097 date "2015-07-01" @default.
• W2121008097 modified "2023-09-27" @default.
• W2121008097 title "A Mixed Phenotype of Airway Wall Thickening and Emphysema Is Associated with Dyspnea and Hospitalization for Chronic Obstructive Pulmonary Disease" @default.
• W2121008097 cites W137920967 @default.
• W2121008097 cites W1513618424 @default.
• W2121008097 cites W1602966110 @default.
• W2121008097 cites W1859222707 @default.
• W2121008097 cites W1863440143 @default.
• W2121008097 cites W1973530626 @default.
• W2121008097 cites W1975762617 @default.
• W2121008097 cites W1982341999 @default.
• W2121008097 cites W2000862536 @default.
• W2121008097 cites W2002726093 @default.
• W2121008097 cites W2020707691 @default.
• W2121008097 cites W2021331487 @default.
• W2121008097 cites W2034050702 @default.
• W2121008097 cites W2043303420 @default.
• W2121008097 cites W2054404145 @default.
• W2121008097 cites W2066721282 @default.
• W2121008097 cites W2068341684 @default.
• W2121008097 cites W2069875525 @default.
• W2121008097 cites W2086335124 @default.
• W2121008097 cites W2098281801 @default.
• W2121008097 cites W2100080030 @default.
• W2121008097 cites W2109676782 @default.
• W2121008097 cites W2112662842 @default.
• W2121008097 cites W2124879124 @default.
• W2121008097 cites W2125078269 @default.
• W2121008097 cites W2125532863 @default.
• W2121008097 cites W2126989218 @default.
• W2121008097 cites W2129846369 @default.
• W2121008097 cites W2131118203 @default.
• W2121008097 cites W2133498143 @default.
• W2121008097 cites W2138021835 @default.
• W2121008097 cites W2138530225 @default.
• W2121008097 cites W2139131213 @default.
• W2121008097 cites W2140357849 @default.
• W2121008097 cites W2141922649 @default.
• W2121008097 cites W2142096203 @default.
• W2121008097 cites W2150264242 @default.
• W2121008097 cites W2152530209 @default.
• W2121008097 cites W2155664876 @default.
• W2121008097 cites W2161713331 @default.
• W2121008097 cites W2165775615 @default.
• W2121008097 cites W2167070869 @default.
• W2121008097 cites W2169756967 @default.
• W2121008097 cites W2169934928 @default.
• W2121008097 cites W2171506107 @default.
• W2121008097 cites W2171647346 @default.
• W2121008097 cites W2171676943 @default.
• W2121008097 cites W2319224774 @default.
• W2121008097 cites W4241996101 @default.
• W2121008097 cites W4246364780 @default.
• W2121008097 doi "https://doi.org/10.1513/annalsats.201411-501oc" @default.
• W2121008097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25844673" @default.
• W2121008097 hasPublicationYear "2015" @default.
• W2121008097 type Work @default.
• W2121008097 sameAs 2121008097 @default.
• W2121008097 citedByCount "37" @default.
• W2121008097 countsByYear W21210080972015 @default.
• W2121008097 countsByYear W21210080972016 @default.
• W2121008097 countsByYear W21210080972017 @default.
• W2121008097 countsByYear W21210080972018 @default.
• W2121008097 countsByYear W21210080972019 @default.
• W2121008097 countsByYear W21210080972020 @default.
• W2121008097 countsByYear W21210080972021 @default.
• W2121008097 countsByYear W21210080972023 @default.
• W2121008097 crossrefType "journal-article" @default.
• W2121008097 hasAuthorship W2121008097A5003913659 @default.
• W2121008097 hasAuthorship W2121008097A5006616360 @default.
• W2121008097 hasAuthorship W2121008097A5009383534 @default.
• W2121008097 hasAuthorship W2121008097A5014772441 @default.
• W2121008097 hasAuthorship W2121008097A5020071687 @default.
• W2121008097 hasAuthorship W2121008097A5034085198 @default.
• W2121008097 hasAuthorship W2121008097A5039052833 @default.
• W2121008097 hasAuthorship W2121008097A5058795367 @default.
• W2121008097 hasAuthorship W2121008097A5059309177 @default.
• W2121008097 hasAuthorship W2121008097A5059646510 @default.
• W2121008097 hasAuthorship W2121008097A5063352775 @default.
• W2121008097 hasAuthorship W2121008097A5068191768 @default.
• W2121008097 hasAuthorship W2121008097A5071650875 @default.

• next