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- W2121023927 abstract "We propose a new and original concept for the precise positioning and the geometrical retention of self-assembled magnetic microbeads in a structured microchannel. When brought in a homogeneous magnetic field, a solution of 500 nm diameter magnetic microbeads self-assembles in magnetic chains in the large sections of a periodically enlarge microchannel, thereby decreasing their magnetic dipolar energy. The self-assembled magnetic chains are retained over the cross-section of the microchannel in a flow velocity up to ~1 mm.s <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>-1</sup> , and strongly interact with the analytes of the solution. Our device is able to perform full on-chip direct and sandwich immuno-assays, in a total assay time of less than 30 min. It consumes nanoliters of sample and reagent solutions, with a fluorescent detection limit of ~1 ng.mL <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>-1</sup> for biotinylated rabbit immunoglobulin G (IgG) and mouse IgG in the direct and two-site immuno-assay test, respectively." @default.
- W2121023927 created "2016-06-24" @default.
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- W2121023927 date "2008-01-01" @default.
- W2121023927 modified "2023-10-01" @default.
- W2121023927 title "Magnetic beads retention device for on-chip sandwich immuno-assay" @default.
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- W2121023927 doi "https://doi.org/10.1109/memsys.2008.4443623" @default.
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