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- W2121024774 abstract "Indirect immunofluorescence revealed that 13% of BALB/c and 33% of CBA spleen cells of B type carry specific binding sites at their surface for double-stranded poly(I)·poly(C). Pretreatment of BALB/c spleen cells with anti-mouse immunoglobulin serum increased the number of B cells capable of binding poly(I)·poly(C) indicating the existence of a second B lymphocyte subpopulation carrying masked poly(I)·poly(C)-binding sites. Pretreatment of the cells with mitogenic doses of either lipopolysaccharide (LPS) or single-stranded polynucleotides, e.g. poly(I) or double-stranded poly(A)·poly(U), failed to affect binding of poly(I)·poly(C) to the cells. Poly(I)·poly(C) converts small poly(I)·poly(C)-binding lymphocytes into lymphoblasts carrying poly(I)·poly(C)-binding sites. Lymphoblasts derived from LPS-stimulated cells do not carry poly(I)·poly(C)-binding sites. Thymocytes or splenic T cells failed to bind poly(I)·poly(C). As measured by thymidine uptake, CBA mice containing a higher percentage of poly(I)·poly(C)-binding cells, are high responder mice to poly(I)·poly(C), compared with low responder BALB/c mice." @default.
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- W2121024774 title "Specific binding of poly(I) · poly(C) to the membrane of murine B lymphocyte subsets" @default.
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- W2121024774 doi "https://doi.org/10.1002/eji.1830081213" @default.
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