Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121036176> ?p ?o ?g. }
- W2121036176 endingPage "184" @default.
- W2121036176 startingPage "176" @default.
- W2121036176 abstract "Previous studies have demonstrated that during respiratory stress (hypercapnia and hypoxia), a latent crossed respiratory pathway can be activated to produce hemidiaphragm recovery following an ipsilateral C2 spinal cord hemisection. The present study investigates the effects of ventral medullary chemoreceptor area stimulation by microinjection of (1S,3R)-aminocyclopentanedicarboxylic acid (ACPD), a glutamate metabotropic receptor agonist, on activating the latent pathway following left C2 spinal cord hemisection in rats in which end-tidal CO2 was maintained at a constant level. Experiments were conducted on anesthetized, vagotomized, paralyzed, and artificially ventilated rats in which phrenic nerve activity was recorded bilaterally. Before drug injection, the phrenic nerve contralateral to hemisection showed vigorous respiratory-related activity, but the phrenic nerve ipsilateral to hemisection showed no discernible respiratory-related activity. ACPD (1–100 nl, 1 mM) was injected directly into the region of the retrotrapezoid nucleus (RTN), a known medullary chemoreceptor area. Microinjection of ACPD into the right RTN increased respiratory-related activity in the right phrenic nerve (contralateral to hemisection). ACPD (>5 nl, 1 mM) microinjection also significantly induced respiratory recovery in the phrenic nerve ipsilateral to hemisection in a dose-dependent manner. The present study indicates that respiratory recovery can be achieved by stimulation of respiratory circuitry without increasing CO2 levels." @default.
- W2121036176 created "2016-06-24" @default.
- W2121036176 creator A5051784453 @default.
- W2121036176 creator A5069711041 @default.
- W2121036176 creator A5082244642 @default.
- W2121036176 date "2001-09-01" @default.
- W2121036176 modified "2023-09-29" @default.
- W2121036176 title "Activation of a Latent Respiratory Motor Pathway by Stimulation of Neurons in the Medullary Chemoreceptor Area of the Rat" @default.
- W2121036176 cites W1750942102 @default.
- W2121036176 cites W1759460249 @default.
- W2121036176 cites W1932398554 @default.
- W2121036176 cites W1964917067 @default.
- W2121036176 cites W1970739624 @default.
- W2121036176 cites W1972280764 @default.
- W2121036176 cites W1976230683 @default.
- W2121036176 cites W1976800529 @default.
- W2121036176 cites W1979004829 @default.
- W2121036176 cites W1987029049 @default.
- W2121036176 cites W1994380941 @default.
- W2121036176 cites W2005767445 @default.
- W2121036176 cites W2019928619 @default.
- W2121036176 cites W2023400938 @default.
- W2121036176 cites W2027997507 @default.
- W2121036176 cites W2036208132 @default.
- W2121036176 cites W2045712239 @default.
- W2121036176 cites W2049475620 @default.
- W2121036176 cites W2052509587 @default.
- W2121036176 cites W2064813399 @default.
- W2121036176 cites W2067421400 @default.
- W2121036176 cites W2079279101 @default.
- W2121036176 cites W2080659626 @default.
- W2121036176 cites W2090315192 @default.
- W2121036176 cites W2124579676 @default.
- W2121036176 cites W2163815564 @default.
- W2121036176 cites W2182617772 @default.
- W2121036176 cites W2226930246 @default.
- W2121036176 cites W2238183238 @default.
- W2121036176 cites W2239704379 @default.
- W2121036176 cites W2258364046 @default.
- W2121036176 cites W2342995321 @default.
- W2121036176 cites W2439853690 @default.
- W2121036176 cites W2441669482 @default.
- W2121036176 cites W2602579630 @default.
- W2121036176 cites W2602918403 @default.
- W2121036176 cites W2604069644 @default.
- W2121036176 cites W2608958515 @default.
- W2121036176 doi "https://doi.org/10.1006/exnr.2001.7740" @default.
- W2121036176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11520132" @default.
- W2121036176 hasPublicationYear "2001" @default.
- W2121036176 type Work @default.
- W2121036176 sameAs 2121036176 @default.
- W2121036176 citedByCount "9" @default.
- W2121036176 countsByYear W21210361762012 @default.
- W2121036176 countsByYear W21210361762013 @default.
- W2121036176 countsByYear W21210361762018 @default.
- W2121036176 countsByYear W21210361762021 @default.
- W2121036176 countsByYear W21210361762023 @default.
- W2121036176 crossrefType "journal-article" @default.
- W2121036176 hasAuthorship W2121036176A5051784453 @default.
- W2121036176 hasAuthorship W2121036176A5069711041 @default.
- W2121036176 hasAuthorship W2121036176A5082244642 @default.
- W2121036176 hasConcept C103247709 @default.
- W2121036176 hasConcept C126322002 @default.
- W2121036176 hasConcept C169760540 @default.
- W2121036176 hasConcept C170493617 @default.
- W2121036176 hasConcept C24998067 @default.
- W2121036176 hasConcept C2777037550 @default.
- W2121036176 hasConcept C2777099253 @default.
- W2121036176 hasConcept C2778110749 @default.
- W2121036176 hasConcept C2780775167 @default.
- W2121036176 hasConcept C42219234 @default.
- W2121036176 hasConcept C529278444 @default.
- W2121036176 hasConcept C534529494 @default.
- W2121036176 hasConcept C62525196 @default.
- W2121036176 hasConcept C71924100 @default.
- W2121036176 hasConcept C86803240 @default.
- W2121036176 hasConceptScore W2121036176C103247709 @default.
- W2121036176 hasConceptScore W2121036176C126322002 @default.
- W2121036176 hasConceptScore W2121036176C169760540 @default.
- W2121036176 hasConceptScore W2121036176C170493617 @default.
- W2121036176 hasConceptScore W2121036176C24998067 @default.
- W2121036176 hasConceptScore W2121036176C2777037550 @default.
- W2121036176 hasConceptScore W2121036176C2777099253 @default.
- W2121036176 hasConceptScore W2121036176C2778110749 @default.
- W2121036176 hasConceptScore W2121036176C2780775167 @default.
- W2121036176 hasConceptScore W2121036176C42219234 @default.
- W2121036176 hasConceptScore W2121036176C529278444 @default.
- W2121036176 hasConceptScore W2121036176C534529494 @default.
- W2121036176 hasConceptScore W2121036176C62525196 @default.
- W2121036176 hasConceptScore W2121036176C71924100 @default.
- W2121036176 hasConceptScore W2121036176C86803240 @default.
- W2121036176 hasIssue "1" @default.
- W2121036176 hasLocation W21210361761 @default.
- W2121036176 hasLocation W21210361762 @default.
- W2121036176 hasOpenAccess W2121036176 @default.
- W2121036176 hasPrimaryLocation W21210361761 @default.
- W2121036176 hasRelatedWork W108346532 @default.
- W2121036176 hasRelatedWork W1150427182 @default.