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• W2121042011 abstract "A 30-year-old man presented with livid-red to brownish, strongly infiltrated, and markedly elevated plaques of 1–5 cm in diameter with fine scaling on the buttocks, lower trunk, and lower extremities of 2 years’ duration (Figs 1 and 2). Complete blood cell count and routine serum chemistry were within normal limits, with the exception of erythrocyte sedimentation rates of 18 and 36 mm in the first and second hour, respectively, and a C-reactive protein level of 8.1 mg/dL. Serum angiotensin converting enzyme (ACE) levels were elevated at 90 U/L (normal values, 18–60 U/L), while serum lysozyme levels, vitamin D, and calcium were normal. The patient presented an anergic reaction to the seven antigens of Multitest Merieux.Figure Figure 1 . Livid-red to brownish, deeply infiltrated, and markedly elevated plaques on the lower trunk and buttocksDownload figure to PowerPointFigure 2. Close-up picture of the plaques on the lower trunkDownload figure to PowerPointHistopathology of the skin lesions revealed typical, but very large, noncaseating, naked, epithelioid cell granulomas throughout the dermis (Fig. 3). Chest X-ray revealed bilateral hilar and mediastinal lymph node enlargement with reticular–nodular shadowing in both lung fields (Fig. 4). Lung function test diagnosed a middle-grade restrictive ventilatory defect. Myocardial scintigraphy with thallium-201 showed evidence of defective uptake in the anterior, posterior, and apical regions of the left ventricle which was compatible with cardiac involvement (Fig. 5). Abdominal ultrasound showed mild hepatosplenomegaly (liver, 16 cm in medioclavicular line; spleen, 12.3 cm longitudinal diameter). X-Ray of the hands detected a 1-cm cyst in the proximal phalanx of the left index finger (Fig. 6). Eye and neurologic examination were normal.Figure 3. Histopathology shows noncaseating, naked, epithelioid cell granulomas throughout the dermis with a typical Langhans giant cell surrounded by thin lymphocytic infiltratesDownload figure to PowerPointFigure 4. Chest X-ray reveals bilateral hilar and mediastinal lymph node enlargement with reticular–nodular shadowing in both lung fieldsDownload figure to PowerPointFigure 5. Myocardial scintigraphy with thallium-201 shows evidence of reduced uptake in the anterior, posterior, and apical regions of the left ventricleDownload figure to PowerPointFigure 6. X-ray of the hands shows a 1 cm cyst in the proximal phalanx of the left index fingerDownload figure to PowerPointDespite the clinical picture of the skin lesions, which was compatible with cutaneous B-cell lymphoma, our findings were compatible with stage II intrathoracic and systemic sarcoidosis with atypical cutaneous plaque-type lesions, lung, mesothoracic lymph node, heart, spleen, liver, and bone involvement. Thus, the patient was treated initially with prednisolone, 50 mg orally, tapered to 10 mg over a period of 8 weeks, and chloroquine, 250 mg orally daily. Three weeks after steroid therapy, there was marked clinical improvement, as well as improvement of inflammatory markers and normalization of serum ACE levels (19.4 U/L). The patient was followed up for 6 months and showed flattening of the skin lesions to macules with color brightening, as well as stabilization of the systemic disease (Fig. 7).Figure 7. Follow-up after 6 months: flattening of the skin lesions and brightening of their colorDownload figure to PowerPoint" @default.
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• W2121042011 date "2002-04-01" @default.
• W2121042011 modified "2023-09-24" @default.
• W2121042011 title "Impressive skin manifestation of systemic sarcoidosis" @default.
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• W2121042011 doi "https://doi.org/10.1046/j.1365-4362.2002.14141.x" @default.
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