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- W2121064105 abstract "Thymic carcinoma is a rare but aggressive thymic neoplasm. The optimal regimen of chemotherapy for thymic carcinoma in the second and subsequent lines of therapy remains unclear. We report a case of a patient with thymic carcinoma who showed a response of stable disease to third-line chemotherapy with single-agent amrubicin (AMR), a synthetic anthracycline analogue and potent DNA topoisomerase II inhibitor. A 57-year-old man was diagnosed with thymic carcinoma complicated by pleural dissemination and pulmonary metastasis. When a recurrence was diagnosed after CODE (cisplatin, vincristine, doxorubicin, etoposide) combination chemotherapy and subsequent carboplatin (CBDCA) plus paclitaxel combination chemotherapy as a second-line therapy, AMR was administered as a 5minute intravenous infusion at a dose of 40 mg/m 2 daily on three consecutive days, every 3 weeks. Four cycles of AMR were administered, and stable disease was confirmed. There were no severe hematological or non-hematological toxicities. It was concluded that AMR can be an effective therapeutic option for advanced thymic carcinoma. To our knowledge this is the first report to demonstrate an activity of AMR against thymic carcinoma in a third-line setting." @default.
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- W2121064105 date "2011-09-01" @default.
- W2121064105 modified "2023-09-28" @default.
- W2121064105 title "Advanced thymic carcinoma showing a stable disease reaction to single-agent amrubicin as a third-line chemotherapy: case report" @default.
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