Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121077787> ?p ?o ?g. }
- W2121077787 endingPage "598" @default.
- W2121077787 startingPage "589" @default.
- W2121077787 abstract "A plethora of cellular processes, including apoptosis, depend on regulated changes in mitochondrial shape and ultrastructure. The role of mitochondria and of their morphology during autophagy, a bulk degradation and recycling process of eukaryotic cells’ constituents, is not well understood. Here we show that mitochondrial morphology determines the cellular response to macroautophagy. When autophagy is triggered, mitochondria elongate in vitro and in vivo. During starvation, cellular cyclic AMP levels increase and protein kinase A (PKA) is activated. PKA in turn phosphorylates the pro-fission dynamin-related protein 1 (DRP1), which is therefore retained in the cytoplasm, leading to unopposed mitochondrial fusion. Elongated mitochondria are spared from autophagic degradation, possess more cristae, increased levels of dimerization and activity of ATP synthase, and maintain ATP production. Conversely, when elongation is genetically or pharmacologically blocked, mitochondria consume ATP, precipitating starvation-induced death. Thus, regulated changes in mitochondrial morphology determine the fate of the cell during autophagy. Mitochondria are found to fuse at the onset of autophagy. This event, which is regulated by a cyclic AMP–PKA (protein kinase A) signalling pathway, increases ATP synthase activity to prevent starvation-induced cell death." @default.
- W2121077787 created "2016-06-24" @default.
- W2121077787 creator A5043923588 @default.
- W2121077787 creator A5051195022 @default.
- W2121077787 creator A5066121404 @default.
- W2121077787 date "2011-04-10" @default.
- W2121077787 modified "2023-10-18" @default.
- W2121077787 title "During autophagy mitochondria elongate, are spared from degradation and sustain cell viability" @default.
- W2121077787 cites W1923133867 @default.
- W2121077787 cites W1946207508 @default.
- W2121077787 cites W1971748110 @default.
- W2121077787 cites W1974096051 @default.
- W2121077787 cites W1974958475 @default.
- W2121077787 cites W1979645469 @default.
- W2121077787 cites W1981592463 @default.
- W2121077787 cites W1982474356 @default.
- W2121077787 cites W1983216661 @default.
- W2121077787 cites W1989540421 @default.
- W2121077787 cites W1992659717 @default.
- W2121077787 cites W1996427463 @default.
- W2121077787 cites W1999793372 @default.
- W2121077787 cites W2007910752 @default.
- W2121077787 cites W2009741382 @default.
- W2121077787 cites W2013091489 @default.
- W2121077787 cites W2022161896 @default.
- W2121077787 cites W2023283007 @default.
- W2121077787 cites W2030351931 @default.
- W2121077787 cites W2034207498 @default.
- W2121077787 cites W2042196731 @default.
- W2121077787 cites W2045085957 @default.
- W2121077787 cites W2054820743 @default.
- W2121077787 cites W2058250395 @default.
- W2121077787 cites W2060811345 @default.
- W2121077787 cites W2064080426 @default.
- W2121077787 cites W2065018825 @default.
- W2121077787 cites W2073625634 @default.
- W2121077787 cites W2090632954 @default.
- W2121077787 cites W2090734611 @default.
- W2121077787 cites W2090945233 @default.
- W2121077787 cites W2091489629 @default.
- W2121077787 cites W2093361250 @default.
- W2121077787 cites W2094162211 @default.
- W2121077787 cites W2100659636 @default.
- W2121077787 cites W2104412320 @default.
- W2121077787 cites W2106195012 @default.
- W2121077787 cites W2107413005 @default.
- W2121077787 cites W2108086395 @default.
- W2121077787 cites W2109586670 @default.
- W2121077787 cites W2109692759 @default.
- W2121077787 cites W2112884278 @default.
- W2121077787 cites W2114806766 @default.
- W2121077787 cites W2124140045 @default.
- W2121077787 cites W2124652836 @default.
- W2121077787 cites W2125189268 @default.
- W2121077787 cites W2130434635 @default.
- W2121077787 cites W2130758099 @default.
- W2121077787 cites W2132349561 @default.
- W2121077787 cites W2132763961 @default.
- W2121077787 cites W2136709809 @default.
- W2121077787 cites W2138751696 @default.
- W2121077787 cites W2139636031 @default.
- W2121077787 cites W2141188578 @default.
- W2121077787 cites W2144687501 @default.
- W2121077787 cites W2144846851 @default.
- W2121077787 cites W2147551208 @default.
- W2121077787 cites W2149128081 @default.
- W2121077787 cites W2155015733 @default.
- W2121077787 cites W2166432730 @default.
- W2121077787 cites W2172127581 @default.
- W2121077787 doi "https://doi.org/10.1038/ncb2220" @default.
- W2121077787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3088644" @default.
- W2121077787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21478857" @default.
- W2121077787 hasPublicationYear "2011" @default.
- W2121077787 type Work @default.
- W2121077787 sameAs 2121077787 @default.
- W2121077787 citedByCount "1374" @default.
- W2121077787 countsByYear W21210777872012 @default.
- W2121077787 countsByYear W21210777872013 @default.
- W2121077787 countsByYear W21210777872014 @default.
- W2121077787 countsByYear W21210777872015 @default.
- W2121077787 countsByYear W21210777872016 @default.
- W2121077787 countsByYear W21210777872017 @default.
- W2121077787 countsByYear W21210777872018 @default.
- W2121077787 countsByYear W21210777872019 @default.
- W2121077787 countsByYear W21210777872020 @default.
- W2121077787 countsByYear W21210777872021 @default.
- W2121077787 countsByYear W21210777872022 @default.
- W2121077787 countsByYear W21210777872023 @default.
- W2121077787 crossrefType "journal-article" @default.
- W2121077787 hasAuthorship W2121077787A5043923588 @default.
- W2121077787 hasAuthorship W2121077787A5051195022 @default.
- W2121077787 hasAuthorship W2121077787A5066121404 @default.
- W2121077787 hasBestOaLocation W21210777872 @default.
- W2121077787 hasConcept C104317684 @default.
- W2121077787 hasConcept C112243037 @default.
- W2121077787 hasConcept C163950672 @default.
- W2121077787 hasConcept C17619807 @default.
- W2121077787 hasConcept C181199279 @default.