FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121117704> ?p ?o ?g. }

• W2121117704 endingPage "280" @default.
• W2121117704 startingPage "275" @default.
• W2121117704 abstract "The permeation ability of a compound is due principally to its concentration in the vehicle and to its aptitude to cross the stratum corneum of the skin. In this work ex-vivo permeation studies on newly developed formulations containing dehydroepiandrosterone (DHEA) were carried out to investigate vehicles that increase drug permeation through the skin. To enhance the solubility of DHEA, its complex form with alpha-cyclodextrin was used. In addition, the two forms (pure drug and complex form) were introduced in hydrophilic (water), lipophilic (paraffin oil), and microemulsion vehicles to evaluate the synergic effect of cyclodextrins and microemulsion vehicles on solubility and permeation. From the results, DHEA solubility is notably conditioned by the type of the vehicle used: the highest solubilities (both for pure and complex drug forms) were obtained with microemulsion, followed by paraffin oil and water. Moreover, in all the studied vehicles, the c-DHEA was more soluble than DHEA. Permeation profile fluxes showed very interesting differences. That reflect the varying drug forms (pure drug and complex form), vehicles used, and drug concentrations in the vehicles. The major flux was obtained in complex of DHEA with alpha-cyclodextrins in the microemulsion vehicle. Therefore, this type of vehicle and drug form would be very useful in the development of a topical formulation containing DHEA." @default.
• W2121117704 created "2016-06-24" @default.
• W2121117704 creator A5011552282 @default.
• W2121117704 creator A5022527413 @default.
• W2121117704 creator A5032152919 @default.
• W2121117704 creator A5039068740 @default.
• W2121117704 creator A5049499330 @default.
• W2121117704 creator A5081131897 @default.
• W2121117704 creator A5082074763 @default.
• W2121117704 date "2005-01-01" @default.
• W2121117704 modified "2023-09-27" @default.
• W2121117704 title "Solubility and Transdermal Permeation Properties of a Dehydroepiandrosterone Cyclodextrin Complex from Hydrophilic and Lipophilic Vehicles" @default.
• W2121117704 cites W1500491597 @default.
• W2121117704 cites W1543932617 @default.
• W2121117704 cites W1972357087 @default.
• W2121117704 cites W1987153917 @default.
• W2121117704 cites W2001033857 @default.
• W2121117704 cites W2012573360 @default.
• W2121117704 cites W2018387294 @default.
• W2121117704 cites W2020096433 @default.
• W2121117704 cites W2025931802 @default.
• W2121117704 cites W2032619580 @default.
• W2121117704 cites W2035488910 @default.
• W2121117704 cites W2045588696 @default.
• W2121117704 cites W2045800643 @default.
• W2121117704 cites W2057081246 @default.
• W2121117704 cites W2075093181 @default.
• W2121117704 cites W2084940501 @default.
• W2121117704 cites W2095478525 @default.
• W2121117704 cites W2155698973 @default.
• W2121117704 cites W2622828541 @default.
• W2121117704 cites W91604478 @default.
• W2121117704 doi "https://doi.org/10.1080/10717540500176563" @default.
• W2121117704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16188726" @default.
• W2121117704 hasPublicationYear "2005" @default.
• W2121117704 type Work @default.
• W2121117704 sameAs 2121117704 @default.
• W2121117704 citedByCount "30" @default.
• W2121117704 countsByYear W21211177042012 @default.
• W2121117704 countsByYear W21211177042014 @default.
• W2121117704 countsByYear W21211177042017 @default.
• W2121117704 countsByYear W21211177042018 @default.
• W2121117704 countsByYear W21211177042019 @default.
• W2121117704 countsByYear W21211177042020 @default.
• W2121117704 countsByYear W21211177042021 @default.
• W2121117704 countsByYear W21211177042022 @default.
• W2121117704 crossrefType "journal-article" @default.
• W2121117704 hasAuthorship W2121117704A5011552282 @default.
• W2121117704 hasAuthorship W2121117704A5022527413 @default.
• W2121117704 hasAuthorship W2121117704A5032152919 @default.
• W2121117704 hasAuthorship W2121117704A5039068740 @default.
• W2121117704 hasAuthorship W2121117704A5049499330 @default.
• W2121117704 hasAuthorship W2121117704A5081131897 @default.
• W2121117704 hasAuthorship W2121117704A5082074763 @default.
• W2121117704 hasBestOaLocation W21211177041 @default.
• W2121117704 hasConcept C142724271 @default.
• W2121117704 hasConcept C155574463 @default.
• W2121117704 hasConcept C178790620 @default.
• W2121117704 hasConcept C181389837 @default.
• W2121117704 hasConcept C185592680 @default.
• W2121117704 hasConcept C190119865 @default.
• W2121117704 hasConcept C205679159 @default.
• W2121117704 hasConcept C2778370115 @default.
• W2121117704 hasConcept C2779433975 @default.
• W2121117704 hasConcept C41625074 @default.
• W2121117704 hasConcept C43617362 @default.
• W2121117704 hasConcept C50670333 @default.
• W2121117704 hasConcept C55493867 @default.
• W2121117704 hasConcept C58226133 @default.
• W2121117704 hasConcept C71924100 @default.
• W2121117704 hasConcept C98274493 @default.
• W2121117704 hasConceptScore W2121117704C142724271 @default.
• W2121117704 hasConceptScore W2121117704C155574463 @default.
• W2121117704 hasConceptScore W2121117704C178790620 @default.
• W2121117704 hasConceptScore W2121117704C181389837 @default.
• W2121117704 hasConceptScore W2121117704C185592680 @default.
• W2121117704 hasConceptScore W2121117704C190119865 @default.
• W2121117704 hasConceptScore W2121117704C205679159 @default.
• W2121117704 hasConceptScore W2121117704C2778370115 @default.
• W2121117704 hasConceptScore W2121117704C2779433975 @default.
• W2121117704 hasConceptScore W2121117704C41625074 @default.
• W2121117704 hasConceptScore W2121117704C43617362 @default.
• W2121117704 hasConceptScore W2121117704C50670333 @default.
• W2121117704 hasConceptScore W2121117704C55493867 @default.
• W2121117704 hasConceptScore W2121117704C58226133 @default.
• W2121117704 hasConceptScore W2121117704C71924100 @default.
• W2121117704 hasConceptScore W2121117704C98274493 @default.
• W2121117704 hasIssue "5" @default.
• W2121117704 hasLocation W21211177041 @default.
• W2121117704 hasLocation W21211177042 @default.
• W2121117704 hasOpenAccess W2121117704 @default.
• W2121117704 hasPrimaryLocation W21211177041 @default.
• W2121117704 hasRelatedWork W1980146396 @default.
• W2121117704 hasRelatedWork W2021921386 @default.
• W2121117704 hasRelatedWork W2072614860 @default.
• W2121117704 hasRelatedWork W2110929416 @default.
• W2121117704 hasRelatedWork W2121117704 @default.
• W2121117704 hasRelatedWork W2377485175 @default.

• next