Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121126006> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2121126006 endingPage "202" @default.
- W2121126006 startingPage "191" @default.
- W2121126006 abstract "Prior work has shown that the power of adaptive designs with rules for modifying the sample size can always be matched or improved by suitably chosen, standard, group sequential designs. A natural question is whether analogous results hold for other types of adaptive designs. We focus on adaptive enrichment designs, which involve preplanned rules for modifying enrollment criteria based on accrued data in a randomized trial. Such designs often involve multiple hypotheses, e.g., one for the total population and one for a predefined subpopulation, such as those with high disease severity at baseline. We fix the total sample size, and consider overall power, defined as the probability of rejecting at least one false null hypothesis. We present adaptive enrichment designs whose overall power at two alternatives cannot simultaneously be matched by any standard design. In some scenarios there is a substantial gap between the overall power achieved by these adaptive designs and that of any standard design. We also prove that such gains in overall power come at a cost. To attain overall power above what is achievable by certain standard designs, it is necessary to increase power to reject some hypotheses and reduce power to reject others. We demonstrate that adaptive enrichment designs allow certain power trade-offs that are not available when restricting to standard designs." @default.
- W2121126006 created "2016-06-24" @default.
- W2121126006 creator A5014594272 @default.
- W2121126006 date "2014-12-18" @default.
- W2121126006 modified "2023-09-23" @default.
- W2121126006 title "Adaptive randomized trial designs that cannot be dominated by any standard design at the same total sample size" @default.
- W2121126006 cites W2004275808 @default.
- W2121126006 cites W2005624264 @default.
- W2121126006 cites W2016765200 @default.
- W2121126006 cites W2038247201 @default.
- W2121126006 cites W2048014796 @default.
- W2121126006 cites W2048265454 @default.
- W2121126006 cites W2068393255 @default.
- W2121126006 cites W2070311219 @default.
- W2121126006 cites W2094133309 @default.
- W2121126006 cites W2112816227 @default.
- W2121126006 cites W2114850871 @default.
- W2121126006 cites W2115012618 @default.
- W2121126006 cites W2120148445 @default.
- W2121126006 cites W2153403353 @default.
- W2121126006 cites W4230441657 @default.
- W2121126006 doi "https://doi.org/10.1093/biomet/asu057" @default.
- W2121126006 hasPublicationYear "2014" @default.
- W2121126006 type Work @default.
- W2121126006 sameAs 2121126006 @default.
- W2121126006 citedByCount "4" @default.
- W2121126006 countsByYear W21211260062016 @default.
- W2121126006 countsByYear W21211260062017 @default.
- W2121126006 countsByYear W21211260062019 @default.
- W2121126006 crossrefType "journal-article" @default.
- W2121126006 hasAuthorship W2121126006A5014594272 @default.
- W2121126006 hasBestOaLocation W21211260062 @default.
- W2121126006 hasConcept C105795698 @default.
- W2121126006 hasConcept C121332964 @default.
- W2121126006 hasConcept C126255220 @default.
- W2121126006 hasConcept C129848803 @default.
- W2121126006 hasConcept C142724271 @default.
- W2121126006 hasConcept C144024400 @default.
- W2121126006 hasConcept C149923435 @default.
- W2121126006 hasConcept C163258240 @default.
- W2121126006 hasConcept C185592680 @default.
- W2121126006 hasConcept C191988596 @default.
- W2121126006 hasConcept C198531522 @default.
- W2121126006 hasConcept C2908647359 @default.
- W2121126006 hasConcept C2982777018 @default.
- W2121126006 hasConcept C33923547 @default.
- W2121126006 hasConcept C34559072 @default.
- W2121126006 hasConcept C43617362 @default.
- W2121126006 hasConcept C535046627 @default.
- W2121126006 hasConcept C62520636 @default.
- W2121126006 hasConcept C71924100 @default.
- W2121126006 hasConcept C96608239 @default.
- W2121126006 hasConceptScore W2121126006C105795698 @default.
- W2121126006 hasConceptScore W2121126006C121332964 @default.
- W2121126006 hasConceptScore W2121126006C126255220 @default.
- W2121126006 hasConceptScore W2121126006C129848803 @default.
- W2121126006 hasConceptScore W2121126006C142724271 @default.
- W2121126006 hasConceptScore W2121126006C144024400 @default.
- W2121126006 hasConceptScore W2121126006C149923435 @default.
- W2121126006 hasConceptScore W2121126006C163258240 @default.
- W2121126006 hasConceptScore W2121126006C185592680 @default.
- W2121126006 hasConceptScore W2121126006C191988596 @default.
- W2121126006 hasConceptScore W2121126006C198531522 @default.
- W2121126006 hasConceptScore W2121126006C2908647359 @default.
- W2121126006 hasConceptScore W2121126006C2982777018 @default.
- W2121126006 hasConceptScore W2121126006C33923547 @default.
- W2121126006 hasConceptScore W2121126006C34559072 @default.
- W2121126006 hasConceptScore W2121126006C43617362 @default.
- W2121126006 hasConceptScore W2121126006C535046627 @default.
- W2121126006 hasConceptScore W2121126006C62520636 @default.
- W2121126006 hasConceptScore W2121126006C71924100 @default.
- W2121126006 hasConceptScore W2121126006C96608239 @default.
- W2121126006 hasIssue "1" @default.
- W2121126006 hasLocation W21211260061 @default.
- W2121126006 hasLocation W21211260062 @default.
- W2121126006 hasOpenAccess W2121126006 @default.
- W2121126006 hasPrimaryLocation W21211260061 @default.
- W2121126006 hasRelatedWork W1604259489 @default.
- W2121126006 hasRelatedWork W1758504992 @default.
- W2121126006 hasRelatedWork W2121126006 @default.
- W2121126006 hasRelatedWork W2209371798 @default.
- W2121126006 hasRelatedWork W2419504199 @default.
- W2121126006 hasRelatedWork W2883778230 @default.
- W2121126006 hasRelatedWork W2952843659 @default.
- W2121126006 hasRelatedWork W3090624304 @default.
- W2121126006 hasRelatedWork W4220949728 @default.
- W2121126006 hasRelatedWork W4307204158 @default.
- W2121126006 hasVolume "102" @default.
- W2121126006 isParatext "false" @default.
- W2121126006 isRetracted "false" @default.
- W2121126006 magId "2121126006" @default.
- W2121126006 workType "article" @default.