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• W2121127099 abstract "Scientists have studied brain molecules for decades, but it is only in the last few years that a consensus field of molecular neurobiology has emerged (cf Cold Spring Harbor Symposium 1983). A significant aspect of molecular neurobiology is tracking the flow of information from genes into proteins, . and that is the topic of this article. Tremendous progress has been made in understanding the structures and biological properties of macromolecules. This is largely due to tech­ nical advances brought about by molecular biologists studying bacterial phage and animal viruses. These advances, which include the following, have made it possible to investigate the structures of genes, RNA tran­ scripts, and proteins with a rapidity and precision far beyond previous technical know-how: the ability to isolate and amplify fragments of inter­ esting DNA by fusing them with bacterial replicons such as plasmids or phage (DNA cloning); the availability of restriction endonucleases for sequence-specific DNA cleavage and hence controlled handling and analy­ sis of cloned DNA fragments; the use of the retroviral enzyme reverse transcriptase for copying RNA molecules into complementary DNA (eDNA),' which is extremely stable compared to chemically labile RNA," @default.
• W2121127099 created "2016-06-24" @default.
• W2121127099 creator A5046657525 @default.
• W2121127099 date "1988-03-01" @default.
• W2121127099 modified "2023-09-27" @default.
• W2121127099 title "mRNA in the Mammalian Central Nervous System" @default.
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• W2121127099 doi "https://doi.org/10.1146/annurev.ne.11.030188.001105" @default.
• W2121127099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2452595" @default.
• W2121127099 hasPublicationYear "1988" @default.
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