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• W2121139686 abstract "One model for the timing of cytokinesis is based on findings that p34(cdc2) can phosphorylate myosin regulatory light chain (LC20) on inhibitory sites (serines 1 and 2) in vitro (Satterwhite, L.L., M.H. Lohka, K.L. Wilson, T.Y. Scherson, L.J. Cisek, J.L. Corden, and T.D. Pollard. 1992. J. Cell Biol. 118:595-605), and this inhibition is proposed to delay cytokinesis until p34(cdc2) activity falls at anaphase. We have characterized previously several kinase activities associated with the isolated cortical cytoskeleton of dividing sea urchin embryos (Walker, G.R., C.B. Shuster, and D.R. Burgess. 1997. J. Cell Sci. 110:1373-1386). Among these kinases and substrates is p34(cdc2) and LC20. In comparison with whole cell activity, cortical H1 kinase activity is delayed, with maximum levels in cortices prepared from late anaphase/telophase embryos. To determine whether cortical-associated p34(cdc2) influences cortical myosin II activity during cytokinesis, we labeled eggs in vivo with [(32)P]orthophosphate, prepared cortices, and mapped LC20 phosphorylation through the first cell division. We found no evidence of serine 1,2 phosphorylation at any time during mitosis on LC20 from cortically associated myosin. Instead, we observed a sharp rise in serine 19 phosphorylation during anaphase and telophase, consistent with an activating phosphorylation by myosin light chain kinase. However, serine 1,2 phosphorylation was detected on light chains from detergent-soluble myosin II. Furthermore, cells arrested in mitosis by microinjection of nondegradable cyclin B could be induced to form cleavage furrows if the spindle poles were physically placed in close proximity to the cortex. These results suggest that factors independent of myosin II inactivation, such as the delivery of the cleavage stimulus to the cortex, determine the timing of cytokinesis." @default.
• W2121139686 created "2016-06-24" @default.
• W2121139686 creator A5022509828 @default.
• W2121139686 creator A5072815472 @default.
• W2121139686 date "1999-09-06" @default.
• W2121139686 modified "2023-09-27" @default.
• W2121139686 title "Parameters That Specify the Timing of Cytokinesis" @default.
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• W2121139686 doi "https://doi.org/10.1083/jcb.146.5.981" @default.
• W2121139686 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169486" @default.
• W2121139686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10477753" @default.
• W2121139686 hasPublicationYear "1999" @default.
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