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- W2121141263 abstract "AbstractHelicidine is a biological extract prepared from the snail Helix pomatia L. and used in man as an anti-tussive agent. However, its mechanisms of action are not fully defined. In this study, we have investigated a possible relaxant effect of helicidine on guinea-pig airway smooth muscle and evaluated the role of prostanoids and airway epithelium in this relaxation. H. pomatia extract (0.001–1 mg/ml) induced a dose-dependent relaxation of guinea-pig trachea pre-contracted with histamine both in the presence and absence of tracheal epithelium. No significant difference in dose-dependency or magnitude of the relaxation was observed between tracheal segments with or without epithelium (maximal relaxant response of 35 ± 7 and 25 ± 7.5%, respectively). Relaxation of the trachea induced by H. pomatia extract (0.001–1 mg/ml) was inhibited by pretreatment with the cyclooxygenase inhibitor, indomethacin, both in the presence or absence of tracheal epithelium. H. pomatia extract (1 mg/ml) induced a marked and significant increase in prostaglandin E 2 release in tracheal segments with and without epithelium. These results indicate that helicidine possesses a bronchorelaxant activity which is independent of epithelium integrity and which is partly mediated by the release of the relaxant prostanoid, prostaglandin E 2. The origin of prostaglandin E 2 production in the airways remains to be defined." @default.
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- W2121141263 date "1998-01-01" @default.
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- W2121141263 title "The Bronchorelaxant Effect of Helicidine, a Helix Pomatia Extract, Involves Prostaglandin E2 Release" @default.
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- W2121141263 doi "https://doi.org/10.1076/phbi.36.1.13.4622" @default.
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