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• W2121185609 abstract "ABSTRACT The Streptococcus gordonii cell surface glycoprotein GspB mediates high-affinity binding to distinct sialylated carbohydrate structures on human platelets and salivary proteins. GspB is glycosylated in the cytoplasm of S. gordonii and is then transported to the cell surface via a dedicated transport system that includes the accessory Sec components SecA2 and SecY2. The means by which the GspB preprotein is selectively recognized by the accessory Sec system have not been characterized fully. GspB has a 90-residue amino-terminal signal sequence that displays a traditional tripartite structure, with an atypically long amino-terminal (N) region followed by hydrophobic (H) and cleavage regions. In this report, we investigate the relative importance of the N and H regions of the GspB signal peptide for trafficking of the preprotein. The results show that the extended N region does not prevent export by the canonical Sec system. Instead, three glycine residues in the H region not only are necessary for export via the accessory Sec pathway but also interfere with export via the canonical Sec route. Replacement of the H-region glycine residues with helix-promoting residues led to a decrease in the efficiency of SecA2-dependent transport of the preprotein and a simultaneous increase in SecA2-independent translocation. Thus, the hydrophobic core of the GspB signal sequence is responsible primarily for routing towards the accessory Sec system." @default.
• W2121185609 created "2016-06-24" @default.
• W2121185609 creator A5022472366 @default.
• W2121185609 creator A5038808498 @default.
• W2121185609 creator A5080734226 @default.
• W2121185609 date "2007-05-15" @default.
• W2121185609 modified "2023-10-05" @default.
• W2121185609 title "Glycine Residues in the Hydrophobic Core of the GspB Signal Sequence Route Export toward the Accessory Sec Pathway" @default.
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• W2121185609 doi "https://doi.org/10.1128/jb.00027-07" @default.
• W2121185609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1913339" @default.
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• W2121185609 hasPublicationYear "2007" @default.
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