FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121240018> ?p ?o ?g. }

• W2121240018 endingPage "6992" @default.
• W2121240018 startingPage "6987" @default.
• W2121240018 abstract "Thyroglobulin (Tg)-specific Abs occur commonly in thyroid disease, but it is not clear to what extent they affect Tg processing and presentation to T cells. Here we show that generation of the nondominant pathogenic Tg epitope (2549-2560), containing thyroxine (T4) at position 2553 (T4(2553)), is augmented by Tg-specific IgG mAbs that facilitate FcR-mediated internalization of Tg. However, other mAbs of the same (IgG1) subclass enhanced Tg uptake by APC but had no effect on the generation of this peptide. Treatment of APC with chloroquine or glutaraldehyde abrogated enhanced generation of T4(2553). The boosting effect was selective, since the enhancing mAbs did not facilitate generation of the neighboring cryptic (2495-2511) peptide, which is also pathogenic in mice. When Tg was simultaneously complexed to a mAb reactive with T4(2553) and to a mixture of boosting mAbs, the presentation of this epitope was totally suppressed. These results suggest that Tg-specific Abs alter Tg processing and may boost or suppress the presentation of nondominant pathogenic determinants during the course of disease." @default.
• W2121240018 created "2016-06-24" @default.
• W2121240018 creator A5000070038 @default.
• W2121240018 creator A5019533468 @default.
• W2121240018 creator A5025440962 @default.
• W2121240018 creator A5038900921 @default.
• W2121240018 creator A5063410244 @default.
• W2121240018 creator A5072637382 @default.
• W2121240018 creator A5087398770 @default.
• W2121240018 date "1999-06-15" @default.
• W2121240018 modified "2023-09-27" @default.
• W2121240018 title "Enhancing or Suppressive Effects of Antibodies on Processing of a Pathogenic T Cell Epitope in Thyroglobulin" @default.
• W2121240018 cites W1551760143 @default.
• W2121240018 cites W1564770796 @default.
• W2121240018 cites W1566165411 @default.
• W2121240018 cites W1606873461 @default.
• W2121240018 cites W1608755119 @default.
• W2121240018 cites W1644553024 @default.
• W2121240018 cites W1749007079 @default.
• W2121240018 cites W1964078166 @default.
• W2121240018 cites W1978574748 @default.
• W2121240018 cites W1989800824 @default.
• W2121240018 cites W1995477488 @default.
• W2121240018 cites W1998721237 @default.
• W2121240018 cites W2000724165 @default.
• W2121240018 cites W2005768107 @default.
• W2121240018 cites W2030783939 @default.
• W2121240018 cites W2039552198 @default.
• W2121240018 cites W2040209854 @default.
• W2121240018 cites W2043747248 @default.
• W2121240018 cites W2044316391 @default.
• W2121240018 cites W2046928933 @default.
• W2121240018 cites W2051150734 @default.
• W2121240018 cites W2060473055 @default.
• W2121240018 cites W2061241669 @default.
• W2121240018 cites W2065001328 @default.
• W2121240018 cites W2067909612 @default.
• W2121240018 cites W2088477504 @default.
• W2121240018 cites W2093003411 @default.
• W2121240018 cites W2122443492 @default.
• W2121240018 cites W2126972494 @default.
• W2121240018 cites W2128857705 @default.
• W2121240018 cites W2137141532 @default.
• W2121240018 cites W2138590651 @default.
• W2121240018 cites W2139753792 @default.
• W2121240018 cites W2142627742 @default.
• W2121240018 cites W2149729349 @default.
• W2121240018 cites W2162283184 @default.
• W2121240018 cites W2163251224 @default.
• W2121240018 cites W2163357710 @default.
• W2121240018 cites W2254490188 @default.
• W2121240018 cites W2404488096 @default.
• W2121240018 doi "https://doi.org/10.4049/jimmunol.162.12.6987" @default.
• W2121240018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10358139" @default.
• W2121240018 hasPublicationYear "1999" @default.
• W2121240018 type Work @default.
• W2121240018 sameAs 2121240018 @default.
• W2121240018 citedByCount "46" @default.
• W2121240018 countsByYear W21212400182012 @default.
• W2121240018 countsByYear W21212400182013 @default.
• W2121240018 countsByYear W21212400182017 @default.
• W2121240018 countsByYear W21212400182020 @default.
• W2121240018 crossrefType "journal-article" @default.
• W2121240018 hasAuthorship W2121240018A5000070038 @default.
• W2121240018 hasAuthorship W2121240018A5019533468 @default.
• W2121240018 hasAuthorship W2121240018A5025440962 @default.
• W2121240018 hasAuthorship W2121240018A5038900921 @default.
• W2121240018 hasAuthorship W2121240018A5063410244 @default.
• W2121240018 hasAuthorship W2121240018A5072637382 @default.
• W2121240018 hasAuthorship W2121240018A5087398770 @default.
• W2121240018 hasConcept C153911025 @default.
• W2121240018 hasConcept C159654299 @default.
• W2121240018 hasConcept C185592680 @default.
• W2121240018 hasConcept C195616568 @default.
• W2121240018 hasConcept C203014093 @default.
• W2121240018 hasConcept C2778835679 @default.
• W2121240018 hasConcept C2779281246 @default.
• W2121240018 hasConcept C542903549 @default.
• W2121240018 hasConcept C55493867 @default.
• W2121240018 hasConcept C86803240 @default.
• W2121240018 hasConceptScore W2121240018C153911025 @default.
• W2121240018 hasConceptScore W2121240018C159654299 @default.
• W2121240018 hasConceptScore W2121240018C185592680 @default.
• W2121240018 hasConceptScore W2121240018C195616568 @default.
• W2121240018 hasConceptScore W2121240018C203014093 @default.
• W2121240018 hasConceptScore W2121240018C2778835679 @default.
• W2121240018 hasConceptScore W2121240018C2779281246 @default.
• W2121240018 hasConceptScore W2121240018C542903549 @default.
• W2121240018 hasConceptScore W2121240018C55493867 @default.
• W2121240018 hasConceptScore W2121240018C86803240 @default.
• W2121240018 hasIssue "12" @default.
• W2121240018 hasLocation W21212400181 @default.
• W2121240018 hasLocation W21212400182 @default.
• W2121240018 hasOpenAccess W2121240018 @default.
• W2121240018 hasPrimaryLocation W21212400181 @default.
• W2121240018 hasRelatedWork W195682249 @default.
• W2121240018 hasRelatedWork W1981898410 @default.
• W2121240018 hasRelatedWork W2059923545 @default.

• next