FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121254343> ?p ?o ?g. }

• W2121254343 endingPage "299" @default.
• W2121254343 startingPage "299" @default.
• W2121254343 abstract "Losartan is a selective angiotensin II (Ang II) type 1 (AT1) receptor antagonist which inhibits vascular smooth muscle cells (VSMCs) contraction and proliferation. We hypothesized that losartan may prevent cell proliferation by activating AMP-activated protein kinase (AMPK) in VSMCs. VSMCs were treated with various concentrations of losartan. AMPK activation was measured by Western blot analysis and cell proliferation was measured by MTT assay and flowcytometry. Losartan dose- and time-dependently increased the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC) in VSMCs. Losartan also significantly decreased the Ang II- or 15% FBS-induced VSMC proliferation by inhibiting the expression of cell cycle associated proteins, such as p-Rb, cyclin D, and cyclin E. Compound C, a specific inhibitor of AMPK, or AMPK siRNA blocked the losartan-induced inhibition of cell proliferation and the G0/G1 cell cycle arrest. These data suggest that losartan-induced AMPK activation might attenuate Ang II-induced VSMC proliferation through the inhibition of cell cycle progression." @default.
• W2121254343 created "2016-06-24" @default.
• W2121254343 creator A5002056660 @default.
• W2121254343 creator A5052568474 @default.
• W2121254343 date "2010-01-01" @default.
• W2121254343 modified "2023-09-24" @default.
• W2121254343 title "Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase" @default.
• W2121254343 cites W1497461844 @default.
• W2121254343 cites W1563676220 @default.
• W2121254343 cites W1978763812 @default.
• W2121254343 cites W1982085282 @default.
• W2121254343 cites W1985107143 @default.
• W2121254343 cites W1991369276 @default.
• W2121254343 cites W1993794263 @default.
• W2121254343 cites W2001892130 @default.
• W2121254343 cites W2024182816 @default.
• W2121254343 cites W2028011534 @default.
• W2121254343 cites W2042706232 @default.
• W2121254343 cites W2053466794 @default.
• W2121254343 cites W2067512136 @default.
• W2121254343 cites W2083849298 @default.
• W2121254343 cites W2095454212 @default.
• W2121254343 cites W2095968828 @default.
• W2121254343 cites W2098392215 @default.
• W2121254343 cites W2103450921 @default.
• W2121254343 cites W2107446346 @default.
• W2121254343 cites W2113101845 @default.
• W2121254343 cites W2113273743 @default.
• W2121254343 cites W2117669993 @default.
• W2121254343 cites W2129697991 @default.
• W2121254343 cites W2131033837 @default.
• W2121254343 cites W2135424721 @default.
• W2121254343 cites W2138792619 @default.
• W2121254343 cites W2140387766 @default.
• W2121254343 cites W2151426663 @default.
• W2121254343 cites W2156783035 @default.
• W2121254343 cites W2162424825 @default.
• W2121254343 doi "https://doi.org/10.4196/kjpp.2010.14.5.299" @default.
• W2121254343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2997415" @default.
• W2121254343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21165328" @default.
• W2121254343 hasPublicationYear "2010" @default.
• W2121254343 type Work @default.
• W2121254343 sameAs 2121254343 @default.
• W2121254343 citedByCount "33" @default.
• W2121254343 countsByYear W21212543432012 @default.
• W2121254343 countsByYear W21212543432013 @default.
• W2121254343 countsByYear W21212543432014 @default.
• W2121254343 countsByYear W21212543432015 @default.
• W2121254343 countsByYear W21212543432016 @default.
• W2121254343 countsByYear W21212543432017 @default.
• W2121254343 countsByYear W21212543432018 @default.
• W2121254343 countsByYear W21212543432019 @default.
• W2121254343 countsByYear W21212543432020 @default.
• W2121254343 countsByYear W21212543432021 @default.
• W2121254343 countsByYear W21212543432022 @default.
• W2121254343 countsByYear W21212543432023 @default.
• W2121254343 crossrefType "journal-article" @default.
• W2121254343 hasAuthorship W2121254343A5002056660 @default.
• W2121254343 hasAuthorship W2121254343A5052568474 @default.
• W2121254343 hasBestOaLocation W21212543431 @default.
• W2121254343 hasConcept C11960822 @default.
• W2121254343 hasConcept C123915805 @default.
• W2121254343 hasConcept C126322002 @default.
• W2121254343 hasConcept C134018914 @default.
• W2121254343 hasConcept C1491633281 @default.
• W2121254343 hasConcept C170493617 @default.
• W2121254343 hasConcept C185592680 @default.
• W2121254343 hasConcept C2776780712 @default.
• W2121254343 hasConcept C2779395532 @default.
• W2121254343 hasConcept C2780124434 @default.
• W2121254343 hasConcept C2780288358 @default.
• W2121254343 hasConcept C2908929049 @default.
• W2121254343 hasConcept C29537977 @default.
• W2121254343 hasConcept C2992686903 @default.
• W2121254343 hasConcept C55493867 @default.
• W2121254343 hasConcept C62112901 @default.
• W2121254343 hasConcept C71924100 @default.
• W2121254343 hasConcept C86803240 @default.
• W2121254343 hasConcept C95444343 @default.
• W2121254343 hasConcept C97029542 @default.
• W2121254343 hasConceptScore W2121254343C11960822 @default.
• W2121254343 hasConceptScore W2121254343C123915805 @default.
• W2121254343 hasConceptScore W2121254343C126322002 @default.
• W2121254343 hasConceptScore W2121254343C134018914 @default.
• W2121254343 hasConceptScore W2121254343C1491633281 @default.
• W2121254343 hasConceptScore W2121254343C170493617 @default.
• W2121254343 hasConceptScore W2121254343C185592680 @default.
• W2121254343 hasConceptScore W2121254343C2776780712 @default.
• W2121254343 hasConceptScore W2121254343C2779395532 @default.
• W2121254343 hasConceptScore W2121254343C2780124434 @default.
• W2121254343 hasConceptScore W2121254343C2780288358 @default.
• W2121254343 hasConceptScore W2121254343C2908929049 @default.
• W2121254343 hasConceptScore W2121254343C29537977 @default.
• W2121254343 hasConceptScore W2121254343C2992686903 @default.
• W2121254343 hasConceptScore W2121254343C55493867 @default.
• W2121254343 hasConceptScore W2121254343C62112901 @default.
• W2121254343 hasConceptScore W2121254343C71924100 @default.
• W2121254343 hasConceptScore W2121254343C86803240 @default.

• next