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- W2121258776 abstract "During evolution, reproductive hormones and their receptors in the brain‐pituitary‐gonadal axis have been altered by genetic mechanisms. To understand how the neuroendocrine control of reproduction evolved in mammals, it is important to examine marsupials, the closest group to placental mammals. We hypothesised that at least some of the hormones and receptors found in placental mammals would be present in koala, a marsupial. We examined the expression of koala m RNA for the reproductive molecules. Koala c DNA s were cloned from brain for gonadotrophin‐releasing hormones ( G n RH 1 and G n RH 2) or from pituitary for G n RH receptors, types I and II , follicle‐stimulating hormone ( FSH) β and luteinising hormone ( LH) β, and from gonads for FSH and LH receptors. Deduced proteins were compared by sequence alignment and phylogenetic analysis with those of other vertebrates. In conclusion, the koala expressed m RNA for these eight putative reproductive molecules, whereas at least one of these molecules is missing in some species in the amniote lineage, including humans. In addition, G n RH 1 and 2 are shown by immunohistochemistry to be expressed as proteins in the brain." @default.
- W2121258776 created "2016-06-24" @default.
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- W2121258776 date "2014-11-17" @default.
- W2121258776 modified "2023-10-03" @default.
- W2121258776 title "Molecular Analysis of the Koala Reproductive Hormones and Their Receptors: Gonadotrophin-Releasing Hormone (GnRH), Follicle-Stimulating Hormone β and Luteinising Hormone β with Localisation of GnRH" @default.
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- W2121258776 doi "https://doi.org/10.1111/jne.12208" @default.
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