FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121343911> ?p ?o ?g. }

• W2121343911 endingPage "1424" @default.
• W2121343911 startingPage "1417" @default.
• W2121343911 abstract "Repair rates of mismatched nucleotides located at an activating hotspot of mutation, H-ras codon 12, have been analyzed in vivo in mammalian cells. Repair rates at codon 12 are significantly improved in cells synchronized to the G1 stage of the mammalian cell cycle as compared with non-synchronous cells, demonstrating that mismatch repair mechanisms are active in G1. Repair rates in non-synchronous cells for the same mismatches at a nearby non-hotspot of mutation, H-ras codon 10, are also significantly improved over repair rates at codon 12 in non-synchronous cells, demonstrating that DNA mismatch repair rates can differ depending on the sequence context. These results suggest that inefficiencies in mismatch repair are responsible, at least in part, for the well documented hotspot of mutation at codon 12. Further experiments involving gel-shift analysis demonstrate a mismatch-specific binding factor for which the degree of binding correlates with in vivo repair rates for each mismatch tested at the codon 12 location. This binding factor appears to be the hMutSα heterodimer as identified by monoclonal antibody assay and inhibition of binding by ATP. Furthermore, a lack of binding is observed only for G:A mismatches at the codon 12 location. This lack of binding correlates with the low rate of repair observed in vivo for G:A mismatches at codon 12 versus the improved repair rates for G:A mismatches at codon 10. This may have biological relevance in that G:C→T:A tranversions are a common mutation at this location in naturally occurring human tumors. These results suggest that there is lowered efficiency in the kinetics of mismatch repair at codon 12. Mismatches at this location are therefore more likely to be replicated before repair, thus resulting in a mutation." @default.
• W2121343911 created "2016-06-24" @default.
• W2121343911 creator A5031411642 @default.
• W2121343911 creator A5077497602 @default.
• W2121343911 creator A5086386010 @default.
• W2121343911 date "1999-08-01" @default.
• W2121343911 modified "2023-09-23" @default.
• W2121343911 title "Inefficient in vivo repair of mismatches at an oncogenic hotspot correlated with lack of binding by mismatch repair proteins and with phase of the cell cycle" @default.
• W2121343911 cites W1491345726 @default.
• W2121343911 cites W1498235995 @default.
• W2121343911 cites W1531981873 @default.
• W2121343911 cites W1549582007 @default.
• W2121343911 cites W1560539518 @default.
• W2121343911 cites W1569239054 @default.
• W2121343911 cites W1569389754 @default.
• W2121343911 cites W1587540429 @default.
• W2121343911 cites W1593968937 @default.
• W2121343911 cites W1845321470 @default.
• W2121343911 cites W1962680485 @default.
• W2121343911 cites W1973677994 @default.
• W2121343911 cites W1976056213 @default.
• W2121343911 cites W1976818887 @default.
• W2121343911 cites W1977284533 @default.
• W2121343911 cites W1984468061 @default.
• W2121343911 cites W1993243592 @default.
• W2121343911 cites W1993497237 @default.
• W2121343911 cites W2005344674 @default.
• W2121343911 cites W2012867725 @default.
• W2121343911 cites W2015221134 @default.
• W2121343911 cites W2016286342 @default.
• W2121343911 cites W2016637724 @default.
• W2121343911 cites W2023654659 @default.
• W2121343911 cites W2031249741 @default.
• W2121343911 cites W2042352526 @default.
• W2121343911 cites W2052085780 @default.
• W2121343911 cites W2053827853 @default.
• W2121343911 cites W2064700784 @default.
• W2121343911 cites W2067028787 @default.
• W2121343911 cites W2075637141 @default.
• W2121343911 cites W2086829507 @default.
• W2121343911 cites W2093093764 @default.
• W2121343911 cites W2093648582 @default.
• W2121343911 cites W2110627805 @default.
• W2121343911 cites W2111284995 @default.
• W2121343911 cites W2115602884 @default.
• W2121343911 cites W2118551903 @default.
• W2121343911 cites W2118641088 @default.
• W2121343911 cites W2119562750 @default.
• W2121343911 cites W2141798197 @default.
• W2121343911 cites W2142769506 @default.
• W2121343911 cites W2142786878 @default.
• W2121343911 cites W2144386534 @default.
• W2121343911 cites W2144466703 @default.
• W2121343911 cites W2152371912 @default.
• W2121343911 cites W2156882408 @default.
• W2121343911 cites W2166776471 @default.
• W2121343911 cites W2279453979 @default.
• W2121343911 cites W2329646608 @default.
• W2121343911 cites W2415662541 @default.
• W2121343911 doi "https://doi.org/10.1093/carcin/20.8.1417" @default.
• W2121343911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10426786" @default.
• W2121343911 hasPublicationYear "1999" @default.
• W2121343911 type Work @default.
• W2121343911 sameAs 2121343911 @default.
• W2121343911 citedByCount "14" @default.
• W2121343911 countsByYear W21213439112013 @default.
• W2121343911 crossrefType "journal-article" @default.
• W2121343911 hasAuthorship W2121343911A5031411642 @default.
• W2121343911 hasAuthorship W2121343911A5077497602 @default.
• W2121343911 hasAuthorship W2121343911A5086386010 @default.
• W2121343911 hasBestOaLocation W21213439111 @default.
• W2121343911 hasConcept C104317684 @default.
• W2121343911 hasConcept C134935766 @default.
• W2121343911 hasConcept C153911025 @default.
• W2121343911 hasConcept C195491092 @default.
• W2121343911 hasConcept C29537977 @default.
• W2121343911 hasConcept C501734568 @default.
• W2121343911 hasConcept C54355233 @default.
• W2121343911 hasConcept C552990157 @default.
• W2121343911 hasConcept C60748783 @default.
• W2121343911 hasConcept C75563809 @default.
• W2121343911 hasConcept C86803240 @default.
• W2121343911 hasConcept C95444343 @default.
• W2121343911 hasConceptScore W2121343911C104317684 @default.
• W2121343911 hasConceptScore W2121343911C134935766 @default.
• W2121343911 hasConceptScore W2121343911C153911025 @default.
• W2121343911 hasConceptScore W2121343911C195491092 @default.
• W2121343911 hasConceptScore W2121343911C29537977 @default.
• W2121343911 hasConceptScore W2121343911C501734568 @default.
• W2121343911 hasConceptScore W2121343911C54355233 @default.
• W2121343911 hasConceptScore W2121343911C552990157 @default.
• W2121343911 hasConceptScore W2121343911C60748783 @default.
• W2121343911 hasConceptScore W2121343911C75563809 @default.
• W2121343911 hasConceptScore W2121343911C86803240 @default.
• W2121343911 hasConceptScore W2121343911C95444343 @default.
• W2121343911 hasIssue "8" @default.
• W2121343911 hasLocation W21213439111 @default.
• W2121343911 hasLocation W21213439112 @default.

• next