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• W2121368983 endingPage "75" @default.
• W2121368983 startingPage "70" @default.
• W2121368983 abstract "Intracerebral hemorrhage (ICH) is a pathological condition that accompanies certain neurological diseases like hemorrhagic stroke or brain trauma. Its effects are severely destructive to the brain and can be fatal. There is an entire spectrum of harmful factors which are associated with the pathogenesis of ICH. One of them is a massive release of hemin from the decomposed erythrocytes. It has been previously shown, that hemin can inhibit the large-conductance Ca2 +-regulated potassium channel in the plasma membrane. However, it remained unclear whether this phenomenon applies also to the mitochondrial large-conductance Ca2 +-regulated potassium channel. The aim of the present study was to determine the impact of hemin on the activity of the large conductance Ca2 +-regulated potassium channel in the brain mitochondria (mitoBKCa). In order to do so, we have used a patch-clamp technique and shown that hemin inhibits mitoBKCa in human astrocytoma U-87 MG cell line mitochondria. Since opening of the mitochondrial potassium channels is known to be cytoprotective, we have elucidated whether hemin can attenuate some of the beneficiary effects of potassium channel opening. We have studied the effect of hemin on reactive oxygen species synthesis, and mild mitochondrial uncoupling in isolated rat brain mitochondria. Taken together, our data show that hemin inhibits mitoBKCa and partially abolishes some of the cytoprotective properties of potassium channel opening. Considering the role of the mitoBKCa in cytoprotection, it can be presumed that its inhibition by hemin may be a novel mechanism contributing to the severity of the ICH symptoms. However, the validity of the presented results shall be further verified in an experimental model of ICH." @default.
• W2121368983 created "2016-06-24" @default.
• W2121368983 creator A5008833361 @default.
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• W2121368983 date "2014-07-01" @default.
• W2121368983 modified "2023-10-14" @default.
• W2121368983 title "Hemin inhibits the large conductance potassium channel in brain mitochondria: A putative novel mechanism of neurodegeneration" @default.
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• W2121368983 doi "https://doi.org/10.1016/j.expneurol.2014.04.022" @default.
• W2121368983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24792919" @default.
• W2121368983 hasPublicationYear "2014" @default.
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