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- W2121418433 abstract "Abstract Recent studies revealed that thalidomide (1) has unique and broad pharmacological effects on multi‐targets although the application of 1 in therapy is still controversial. In this study, we synthesized nitrogen‐13‐labeled thalidomide ([ 13 N]1) as a potential positron emission tomography (PET) probe using no‐carrier‐added [ 13 N]NH 3 as a labeling agent. By use of an automated system, [ 13 N]1 was prepared by reacting N ‐phthaloylglutamic anhydride (2) with [ 13 N]NH 3 , following by cyclization with carbonyldiimidazole in a radiochemical yield of 56±12% (based on [ 11 N]NH 3 , corrected for decay) and specific activity of 49±24 GBq/µmol at the end of synthesis (EOS). At EOS, 570–780 MBq ( n =7) of [ 13 N]1 was obtained at a beam current of 15 µA after 15 min proton bombardment with a synthesis time of 14 min from the end of bombardment. Using a small animal PET scanner, preliminary biodistribution of [ 13 N]1 in mice was examined. Copyright © 2010 John Wiley & Sons, Ltd." @default.
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- W2121418433 date "2010-01-14" @default.
- W2121418433 modified "2023-10-12" @default.
- W2121418433 title "Radiosynthesis of<sup>13</sup>N-labeled thalidomide using no-carrier-added [<sup>13</sup>N]NH<sub>3</sub>" @default.
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- W2121418433 doi "https://doi.org/10.1002/jlcr.1699" @default.
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