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• W2121444878 abstract "Cancer stem-like cells, which have been described as tumor-initiating cells or tumor-propagating cells, play a crucial role in our fundamental understanding of glioblastoma multiforme (GBM) and its recurrence. GBM is a lethal cancer, characterized by florid vascularization and aberrantly elevated vascular endothelial growth factor (VEGF). VEGF promotes tumorigenesis and angiogenesis of human GBM stem-like cells (GBSCs). However, whether and how VEGF contributes to GBSCs proliferation remain largely uncertain. In this study, human GBSCs were isolated from surgical specimens of glioblastoma and cultured in medium favored for stem cell growth. Neural Colony-Forming Cell Assay and ATP assay were performed to measure GBSC proliferation under normoxia (20% O 2 ) and hypoxia (1% O 2 ). Our observations demonstrate that exogenous VEGF stimulates GBSC proliferation in a dose-dependent manner via VEGF Receptor 2 (VEGFR2); while VEGF Receptor 1 (VEGFR1) has a negative feedback effect on VEGFR2 when cells were exposed to higher concentration of VEGF. These results suggest that suppressing VEGFR2-dependent GBSC proliferation is a potentially therapeutic strategy in GBM." @default.
• W2121444878 created "2016-06-24" @default.
• W2121444878 creator A5044941594 @default.
• W2121444878 creator A5054871862 @default.
• W2121444878 creator A5058019217 @default.
• W2121444878 date "2013-01-01" @default.
• W2121444878 modified "2023-10-18" @default.
• W2121444878 title "VEGF Promotes Proliferation of Human Glioblastoma Multiforme Stem-Like Cells through VEGF Receptor 2" @default.
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• W2121444878 doi "https://doi.org/10.1155/2013/417413" @default.
• W2121444878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3603324" @default.
• W2121444878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23533349" @default.
• W2121444878 hasPublicationYear "2013" @default.
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