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- W2121445620 endingPage "3936" @default.
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- W2121445620 abstract "TLR4, the innate immunity receptor for bacterial endotoxins, plays a pivotal role in the induction of inflammatory responses. There is a need to develop molecules that block either activation through TLR4 or the downstream signaling pathways to inhibit the storm of inflammation typically elicited by bacterial LPS, which is a major cause of the high mortality associated with bacterial sepsis. We report in this article that a single i.p. injection of 15 μg fatty acid binding protein from Fasciola hepatica (Fh12) 1 h before exposure to LPS suppressed significantly the expression of serum inflammatory cytokines in a model of septic shock using C57BL/6 mice. Because macrophages are a good source of IL-12p70 and TNF-α, and are critical in driving adaptive immunity, we investigated the effect of Fh12 on the function of mouse bone marrow-derived macrophages (bmMΦs). Although Fh12 alone did not induce cytokine expression, it significantly suppressed the expression of IL-12, TNF-α, IL-6, and IL-1β cytokines, as well as inducible NO synthase-2 in bmMΦs, and also impaired the phagocytic capacity of bmMΦs. Fh12 had a limited effect on the expression of inflammatory cytokines induced in response to other TLR ligands. One mechanism used by Fh12 to exert its anti-inflammatory effect is binding to the CD14 coreceptor. Moreover, it suppresses phosphorylation of ERK, p38, and JNK. The potent anti-inflammatory properties of Fh12 demonstrated in this study open doors to further studies directed at exploring the potential of this molecule as a new class of drug against septic shock or other inflammatory diseases." @default.
- W2121445620 created "2016-06-24" @default.
- W2121445620 creator A5026668405 @default.
- W2121445620 creator A5038682303 @default.
- W2121445620 creator A5048080723 @default.
- W2121445620 creator A5067506384 @default.
- W2121445620 date "2015-04-15" @default.
- W2121445620 modified "2023-10-16" @default.
- W2121445620 title "<i>Fasciola hepatica</i> Fatty Acid Binding Protein Inhibits TLR4 Activation and Suppresses the Inflammatory Cytokines Induced by Lipopolysaccharide In Vitro and In Vivo" @default.
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- W2121445620 doi "https://doi.org/10.4049/jimmunol.1401182" @default.
- W2121445620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4390499" @default.
- W2121445620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25780044" @default.
- W2121445620 hasPublicationYear "2015" @default.
- W2121445620 type Work @default.