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• W2121446162 endingPage "C922" @default.
• W2121446162 startingPage "C915" @default.
• W2121446162 abstract "We used the Ca 2+ -sensitive fluorescent dye fura 2, together with measurements of intracellulard- myo-inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ], to assess the inhibitory effects of caffeine on signal transduction via G protein-coupled receptor pathways in isolated rat mandibular salivary acinar cells. ACh, norepinephrine (NE), and substance P (SP) all evoked substantial increases in the intracellular free Ca 2+ concentration ([Ca 2+ ] i ). Responses to ACh and NE were markedly inhibited by prior application of 20 mM caffeine. The inhibitory effect of caffeine was not reproduced by phosphodiesterase inhibition with IBMX or addition of cell-permeant dibutyryl cAMP. In contrast to the ACh and NE responses, the [Ca 2+ ] i response to SP was unaffected by caffeine. Despite this, SP and ACh appeared to mobilize Ca 2+ from a common intracellular pool. Measurements of agonist-induced changes in Ins(1,4,5) P 3 levels confirmed that caffeine inhibited the stimulus-response coupling pathway at a point before Ins(1,4,5) P 3 generation. Caffeine did not, however, inhibit [Ca 2+ ] i responses evoked by direct activation of G proteins with 40 mM F − . These data show that caffeine inhibits G protein-coupled signal transduction in these cells at some element that is common to the muscarinic and α-adrenergic signaling pathways but is not shared by the SP signaling pathway. We suggest that this element might be a specific structural motif on the G protein-coupled muscarinic and α-adrenergic receptors." @default.
• W2121446162 created "2016-06-24" @default.
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• W2121446162 date "1999-04-01" @default.
• W2121446162 modified "2023-09-27" @default.
• W2121446162 title "Caffeine does not inhibit substance P-evoked intracellular Ca²⁺mobilization in rat salivary acinar cells" @default.
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• W2121446162 doi "https://doi.org/10.1152/ajpcell.1999.276.4.c915" @default.
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